Anti-EYA4 antibody (ab110148)
Key features and details
- Goat polyclonal to EYA4
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-EYA4 antibody
See all EYA4 primary antibodies -
Description
Goat polyclonal to EYA4 -
Host species
Goat -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide: DSQDLNEQSVKKTC, corresponding to N terminal amino acids 2-16 of Human EYA4 (UniProt ID: O95677).
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Positive control
- Human liver and testis tissues
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab110148 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 3.75 µg/ml.
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Notes |
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IHC-P
Use a concentration of 3.75 µg/ml. |
Target
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Function
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye. -
Tissue specificity
Highly expressed in heart and skeletal muscle. -
Involvement in disease
Defects in EYA4 are the cause of deafness autosomal dominant type 10 (DFNA10) [MIM:601316]. DFNA10 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Defects in EYA4 are the cause of cardiomyopathy dilated type 1J (CMD1J) [MIM:605362]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. -
Sequence similarities
Belongs to the HAD-like hydrolase superfamily. EYA family. -
Cellular localization
Cytoplasm. Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 2070 Human
- Entrez Gene: 14051 Mouse
- Omim: 603550 Human
- SwissProt: O95677 Human
- SwissProt: Q9Z191 Mouse
- Unigene: 596680 Human
- Unigene: 332128 Mouse
- Unigene: 446298 Mouse
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Alternative names
- CMD1J antibody
- Deafness, autosomal dominant 10 antibody
- DFNA 10 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (0)
ab110148 has not yet been referenced specifically in any publications.