Overview

  • Product name

  • Description

    Rabbit polyclonal to EYA4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Fr, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat, Rabbit, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis, Platypus
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 100-150 of Human EYA4 (NP_004091.3).

  • Positive control

    • Human Ovarian Carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab128147 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent concentration. Likely to work with frozen sections
IHC-P 1/100 - 1/500. Antigen retrieval is recommended and using citrate buffer will enhance staining.

Target

  • Function

    Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.
  • Tissue specificity

    Highly expressed in heart and skeletal muscle.
  • Involvement in disease

    Defects in EYA4 are the cause of deafness autosomal dominant type 10 (DFNA10) [MIM:601316]. DFNA10 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Defects in EYA4 are the cause of cardiomyopathy dilated type 1J (CMD1J) [MIM:605362]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • Sequence similarities

    Belongs to the HAD-like hydrolase superfamily. EYA family.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • CMD1J antibody
    • Deafness, autosomal dominant 10 antibody
    • DFNA 10 antibody
    • DFNA10 antibody
    • dJ78N10.1 (eyes absent (Drosophila) homolog 4) antibody
    • dJ78N10.1 (eyes absent) antibody
    • EYA 4 antibody
    • eya4 antibody
    • EYA4_HUMAN antibody
    • Eyes absent 4 antibody
    • Eyes absent homolog 4 (Drosophila) antibody
    • Eyes absent homolog 4 antibody
    • HGNC:3522 antibody
    • OTTHUMP00000040267 antibody
    see all

Images

  • ab128147, at 1/250, staining in EYA4 formalin fixed, paraffin embedded Human ovarian carcinoma tissue by Immunohistochemistry. Detected using DAB staining.

References

ab128147 has not yet been referenced specifically in any publications.

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