Key features and details
- Rabbit polyclonal to EYA4
- Suitable for: IHC-Fr, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-EYA4 antibody
See all EYA4 primary antibodies
DescriptionRabbit polyclonal to EYA4
Tested applicationsSuitable for: IHC-Fr, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Rat, Rabbit, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis, Platypus
Synthetic peptide, corresponding to a region within amino acids 100-150 of Human EYA4 (NP_004091.3).
- Human Ovarian Carcinoma.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 99% Tris buffered saline, 0.1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab128147 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-Fr||Use at an assay dependent concentration. Likely to work with frozen sections|
|IHC-P||1/100 - 1/500. Antigen retrieval is recommended and using citrate buffer will enhance staining.|
FunctionTyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.
Tissue specificityHighly expressed in heart and skeletal muscle.
Involvement in diseaseDefects in EYA4 are the cause of deafness autosomal dominant type 10 (DFNA10) [MIM:601316]. DFNA10 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Defects in EYA4 are the cause of cardiomyopathy dilated type 1J (CMD1J) [MIM:605362]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Sequence similaritiesBelongs to the HAD-like hydrolase superfamily. EYA family.
Cellular localizationCytoplasm. Nucleus.
- Information by UniProt
- CMD1J antibody
- Deafness, autosomal dominant 10 antibody
- DFNA 10 antibody
ab128147 has not yet been referenced specifically in any publications.