(E,Z)-4-Hydroxytamoxifen (17197F0KYM), estrogen receptor modulator (ab143638)

Overview

  • Product name

    (E,Z)-4-Hydroxytamoxifen (17197F0KYM), estrogen receptor modulator
  • Description

    Potent and selective estrogen receptor modulator
  • Biological description

    Potent and selective estrogen receptor modulator. Mixture of (Z)-4-Hydroxytamoxifen (ab141943) and (E)-4-Hydroxytamoxifen (ab143637) isomers. Tamoxifen (ab120656) metabolite. Inhibits lipid peroxidation. Shows estrogenic and antiestrogenic effects in vivo. Orally active.
  • Purity

    > 97%
  • CAS Number

    68392-35-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
  • Molecular weight

    387.51
  • Molecular formula

    C26H29NO2
  • PubChem identifier

    63062
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kohli L  et al. 4-Hydroxytamoxifen induces autophagic death through K-Ras degradation. Cancer Res 73:4395-405 (2013). Read more (PubMed: 23722551) »
  • Prather PL  et al. CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen. Biochem Biophys Res Commun 441:339-43 (2013). Read more (PubMed: 24148245) »
  • McCague R  et al. Nonisomerizable analogues of (Z)- and (E)-4-hydroxytamoxifen. Synthesis and endocrinological properties of substituted diphenylbenzocycloheptenes. J Med Chem 31:1285-90 (1988). Read more (PubMed: 3385723) »

Customer reviews and Q&As

Answer



Wir haben leider keine Informationen zur Löslichkeit von ab143638 in Wasser und DMSO.

Ich habe Informationen für Ethanol und Methanol gefunden:

Für Ethanol ist die maximale Konzentration 20 mg/ml und für Methanol 10 mg/ml.

Read More

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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