Description

  • Product name

    Ezrin / Radixin / Moesin peptide
  • Animal free

    No
  • Nature

    Synthetic
    • Sequence

      RLGRDKYKTLRQIRQ

Associated products

Specifications

Our Abpromise guarantee covers the use of ab204865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    HPLC

  • Form

    Lyophilised
  • Additional notes

    ab204865 (Ezrin / Radixin / Moesin peptide) can be utilized as a substrate for the  active protein kinase ab177261 (Active human LRRK2 protein fragment)

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Dilute peptide in 20mM Tris-HCl, pH 7.5 solution to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.

General Info

  • Alternative names

    • CVIL
    • CVL
    • Cytovillin
    • Cytovillin 2
    • Deafness autosomal recessive 24
    • DFNB24
    • DKFZp762H157
    • EZR
    • FLJ26216
    • Membrane organizing extension spike protein
    • MGC1584
    • MSN
    • OTTHUMP00000017506
    • OTTHUMP00000017507
    • OTTHUMP00000023438
    • p81
    • RDX
    • VIL2
    • Villin 2
    • Villin 2 ezrin
    • Villin2
    see all
  • Relevance

    Ezrin is a cytoplasmic peripheral membrane protein and functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Moesin is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement.
  • Cellular localization

    Cell Membrane, Cytoskeleton and Cytoplasmic

References

ab204865 has not yet been referenced specifically in any publications.

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