Overview

  • Product name

  • Description

    Rabbit polyclonal to F-spondin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide within Human F-spondin aa 775-807 (C terminal) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    QERYMT VKKRFKSSQF TSCKDKKEIR ACNVHPC


    Database link: Q9HCB6

  • Positive control

    • Rat lung and mouse brain tissue.
  • General notes

     This product was previously labelled as SPON1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab215165 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Relevance

    SPON1 is a member of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of SPON1 proteins are typical of class 2 TSRs. SPON1, which is similar to thrombospondin, is a extracellular matrix attached molecule that promotes neurite outgrowth and inhibits angiogenesis. Analysis of gain and loss of function experiments reveal that SPON1 is required for accurate pathfinding of embryonic axons, and plays a dual role in patterning axonal trajectories. It promotes the outgrowth of commissural and inhibits the outgrowth of motor axons, and has also been implicated in inflammatory processes in the nervous system.
  • Cellular localization

    Secreted protein; extracellular space; extracellular matrix.
  • Database links

  • Alternative names

    • F spondin antibody
    • SPON 1 antibody
    • spondin 1 (f spondin) extracellular matrix protein antibody
    • Spondin 1 antibody
    • Spondin 1 extracellular matrix protein antibody
    • Spondin 1 precursor antibody
    • Spondin1 antibody
    • Vascular smooth muscle cell growth promoting factor antibody
    • VSGP antibody
    • VSGP/F spondin antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse brain tissue labeling F-spondin with ab215165 at 1/400 dilution and DAB staining.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse brain tissue labeling F-spondin with ab215165 at 1/400 dilution and DAB staining.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat lung tissue labeling F-spondin with ab215165 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

References

ab215165 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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