Question (70922) | Anti-F4/80 antibody [CI:A3-1] (ab6640)

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Question

What does kappa monoclonal mean in regards to antibodies?

Answer

There are two types of light chain in humans (as in other mammals),
kappa (κ) chain, encoded by the immunoglobulin kappa locus (IGK@) on chromosome 2 and lambda (λ) chain, encoded by the immunoglobulin lambda locus (IGL@) on chromosome 22

Antibodies are produced by B lymphocytes, each expressing only one class of light chain. Once set, light chain class remains fixed for the life of the B lymphocyte. In a healthy individual, the total kappa to lambda ratio is roughly 2:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of neoplasm.

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