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    factor-b-antibody-6g11-ab17927.pdf

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Immunology Innate Immunity Complement Alternative Pathway
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Anti-Factor B antibody [6G11] (ab17927)

  • Datasheet
  • SDS
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Key features and details

  • Mouse monoclonal [6G11] to Factor B
  • Reacts with: Human
  • Isotype: IgG1

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Overview

  • Product name

    Anti-Factor B antibody [6G11]
    See all Factor B primary antibodies
  • Description

    Mouse monoclonal [6G11] to Factor B
  • Host species

    Mouse
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Factor B isolated from human plasma.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.40
    Preservative: 0.097% Sodium azide
    Constituents: 0.0268% PBS, 2.9% Sodium chloride
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Monoclonal
  • Clone number

    6G11
  • Myeloma

    x63-Ag8.653
  • Isotype

    IgG1
  • Light chain type

    kappa
  • Research areas

    • Immunology
    • Innate Immunity
    • Complement
    • Alternative Pathway

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
  • Recombinant Protein

    • Recombinant Human Factor B protein (ab151392)

Target

  • Function

    Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
  • Involvement in disease

    Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:612924]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
  • Sequence similarities

    Belongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.
    Contains 3 Sushi (CCP/SCR) domains.
    Contains 1 VWFA domain.
  • Cellular localization

    Secreted.
  • Target information above from: UniProt accession P00751 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 629 Human
    • Omim: 138470 Human
    • SwissProt: P00751 Human
    • Unigene: 69771 Human
    • Alternative names

      • AHUS4 antibody
      • B factor properdin antibody
      • BF antibody
      • BFD antibody
      • C3 proaccelerator antibody
      • C3 proactivator antibody
      • C3/C5 convertase antibody
      • CFAB antibody
      • CFAB_HUMAN antibody
      • CFB antibody
      • Complement Factor B antibody
      • Complement factor B Bb fragment antibody
      • FB antibody
      • FBI12 antibody
      • GBG antibody
      • Glycine rich beta glycoprotein antibody
      • Glycine-rich beta glycoprotein antibody
      • H2 Bf antibody
      • H2BF antibody
      • PBF2 antibody
      • Properdin factor B antibody
      see all

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab17927? Please let us know so that we can cite the reference in this datasheet.

    ab17927 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Show All Reviews Q&A
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    Question

    Email: kate@novusbio.com Is this antibody specific for properdin or fragment BA of factor B? These are two different proteins. Thank you.

    Read More

    Abcam community

    Verified customer

    Asked on Feb 10 2006

    Answer

    Thank you for your enquiry. This antibody is specific for properdin because it reacts with the Ba fragment of factor B in the non-reduced form only. Properdin factor B is a 764 amino acid protein. Complement factor B, Ba fragment comprises amino acids 26 to 259 of Properdin factor B. The antibody recognizes an epitope on the BA fragment but only works well on the non-reduced form in Western blotting, hence only the high molecular weight band is observed. Thank you for your question. I have added this information to the datasheet. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    Answered on Feb 10 2006

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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