Key features and details
- Goat polyclonal to Factor B
- Suitable for: IHC-P, Immunodiffusion
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Factor B antibody
See all Factor B primary antibodies
DescriptionGoat polyclonal to Factor B
SpecificityIn immunoelectrophoresis against Human EDTA plasma a single precipitin line is obtained in the beta-2 region. The antiserum does not react with any other protein component of Human serum or plasma. The antiserum does not cross-react with any other Human plasma proteins as tested in gel-diffusion techniques.
Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins, since homologous proteins of different species frequently share antigenic determinants. Cross-reactivity of ab150494 has not been tested in detail, however in double radial immunodiffusion a weak reaction with mouse has been observed.
Tested applicationsSuitable for: IHC-P, Immunodiffusionmore details
Species reactivityReacts with: Human
Human Factor B
- Human adrenal and liver tissues.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab150494 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Immunodiffusion||Use at an assay dependent dilution.|
FunctionFactor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
Involvement in diseaseDefects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:612924]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 3 Sushi (CCP/SCR) domains.
Contains 1 VWFA domain.
- Information by UniProt
- AHUS4 antibody
- B factor properdin antibody
- BF antibody
ab150494 has not yet been referenced specifically in any publications.