Overview

  • Product name

  • Description

    Goat polyclonal to Factor B
  • Host species

    Goat
  • Specificity

    In immunoelectrophoresis against Human EDTA plasma a single precipitin line is obtained in the beta-2 region. The antiserum does not react with any other protein component of Human serum or plasma. The antiserum does not cross-react with any other Human plasma proteins as tested in gel-diffusion techniques.
    Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins, since homologous proteins of different species frequently share antigenic determinants. Cross-reactivity of ab150494 has not been tested in detail, however in double radial immunodiffusion a weak reaction with mouse has been observed.
  • Tested applications

    Suitable for: IHC-P, Immunodiffusionmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Human Factor B

  • Positive control

    • Human adrenal and liver tissues.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab150494 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200.
Immunodiffusion Use at an assay dependent dilution.

Target

  • Function

    Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
  • Involvement in disease

    Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:612924]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
  • Sequence similarities

    Belongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.
    Contains 3 Sushi (CCP/SCR) domains.
    Contains 1 VWFA domain.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • AHUS4 antibody
    • B factor properdin antibody
    • BF antibody
    • BFD antibody
    • C3 proaccelerator antibody
    • C3 proactivator antibody
    • C3/C5 convertase antibody
    • CFAB antibody
    • CFAB_HUMAN antibody
    • CFB antibody
    • Complement Factor B antibody
    • Complement factor B Bb fragment antibody
    • FB antibody
    • FBI12 antibody
    • GBG antibody
    • Glycine rich beta glycoprotein antibody
    • Glycine-rich beta glycoprotein antibody
    • H2 Bf antibody
    • H2BF antibody
    • PBF2 antibody
    • Properdin factor B antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver tissue labelling Factor B with ab150494 at 1/200 dilution.
  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human adrenal tissue labelling Factor B with ab150494 at 1/200 dilution.

References

ab150494 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab150494.
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