Anti-Factor D/CFD antibody [D10/4] (ab121054)
Key features and details
- Mouse monoclonal [D10/4] to Factor D/CFD
- Suitable for: WB, Sandwich ELISA
- Reacts with: Human
- Isotype: IgG2a
Overview
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Product name
Anti-Factor D/CFD antibody [D10/4]
See all Factor D/CFD primary antibodies -
Description
Mouse monoclonal [D10/4] to Factor D/CFD -
Host species
Mouse -
Specificity
ab121054 is specific for complement Factor D/CFD in Human serum and plasma.
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Tested applications
Suitable for: WB, Sandwich ELISAmore details -
Species reactivity
Reacts with: Human -
Immunogen
Full length protein corresponding to Human Factor D/CFD.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.1% Sodium azide
Constituents: 97% Phosphate Buffer, 2.9% Sodium chloride -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
D10/4 -
Myeloma
x63-Ag8.653 -
Isotype
IgG2a -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab121054 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent concentration.
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Sandwich ELISA |
Use at an assay dependent concentration.
as capture antibody. The dilution guideline for ELISA is based on sandwich ELISA in combination with a polyclonal antibody against the antigen. |
Notes |
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WB
Use at an assay dependent concentration. |
Sandwich ELISA
Use at an assay dependent concentration. as capture antibody. The dilution guideline for ELISA is based on sandwich ELISA in combination with a polyclonal antibody against the antigen. |
Target
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Function
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. -
Involvement in disease
Defects in CFD are the cause of complement factor D deficiency (CFD deficiency) [MIM:134350]. CFD deficiency predisposes to invasive meningococcal disease. -
Sequence similarities
Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 1675 Human
- Omim: 134350 Human
- SwissProt: P00746 Human
- Unigene: 155597 Human
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Alternative names
- Adipsin antibody
- Adipsin/complement factor D antibody
- Adn antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab121054 has not yet been referenced specifically in any publications.