Anti-Factor H antibody [EPR6226] (ab124769)


  • Product name
    Anti-Factor H antibody [EPR6226]
    See all Factor H primary antibodies
  • Description
    Rabbit monoclonal [EPR6226] to Factor H
  • Host species
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Factor H aa 900-1000. The exact sequence is proprietary.

  • Positive control
    • A549, Human fetal lung, Human fetal liver, Human kidney and Human plasma lysates
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.


  • Form
  • Storage instructions
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage buffer
    pH: 7.20
    Preservative: 0.05% Sodium azide
    Constituents: 40% Glycerol, 9.85% Tris glycine, 50% Tissue culture supernatant
  • Purity
    Tissue culture supernatant
  • Clonality
  • Clone number
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab124769 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 180 kDa (predicted molecular weight: 139 kDa).
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Function
      Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.
    • Tissue specificity
      Expressed by the liver and secreted in plasma.
    • Involvement in disease
      Genetic variations in CFH are associated with basal laminar drusen (BLD) [MIM:126700]; also known as drusen of Bruch membrane or cuticular drusen or grouped early adult-onset drusen. Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch membrane. Basal laminar drusen refers to an early adult-onset drusen phenotype that shows a pattern of uniform small, slightly raised yellow subretinal nodules randomly scattered in the macula. In later stages, these drusen often become more numerous, with clustered groups of drusen scattered throughout the retina. In time these small basal laminar drusen may expand and ultimately lead to a serous pigment epithelial detachment of the macula that may result in vision loss.
      Defects in CFH are the cause of complement factor H deficiency (CFH deficiency) [MIM:609814]. CFH deficiency determines uncontrolled activation of the alternative complement pathway with consumption of C3 and often other terminal complement components. It is associated with a number of renal diseases with variable clinical presentation and progression, including membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome. CFH deficiency patients may show increased susceptibility to meningococcal infections.
      Defects in CFH are a cause of susceptibility to hemolytic uremic syndrome atypical type 1 (AHUS1) [MIM:235400]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
      Genetic variation in CFH is associated with age-related macular degeneration type 4 (ARMD4) [MIM:610698]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
    • Sequence similarities
      Contains 20 Sushi (CCP/SCR) domains.
    • Cellular localization
    • Information by UniProt
    • Database links
    • Alternative names
      • adrenomedullin binding protein antibody
      • age related maculopathy susceptibility 1 antibody
      • AHUS 1 antibody
      • AHUS1 antibody
      • AMBP 1 antibody
      • AMBP1 antibody
      • ARMD 4 antibody
      • ARMD4 antibody
      • ARMS 1 antibody
      • ARMS1 antibody
      • beta 1 H globulin antibody
      • beta 1H antibody
      • beta1H antibody
      • CFAH_HUMAN antibody
      • CFH antibody
      • CFHL 3 antibody
      • CFHL3 antibody
      • Complement factor H antibody
      • complement factor H, isoform b antibody
      • Factor H antibody
      • factor H like 1 antibody
      • FH antibody
      • FHL 1 antibody
      • FHL1 antibody
      • H factor 1 (complement) antibody
      • H factor 1 antibody
      • H factor 2 (complement) antibody
      • HF 1 antibody
      • HF 2 antibody
      • HF antibody
      • HF1 antibody
      • HF2 antibody
      • HUS antibody
      • MGC88246 antibody
      see all


    • All lanes : Anti-Factor H antibody [EPR6226] (ab124769) at 1/1000 dilution

      Lane 1 : A549 cell lysate
      Lane 2 : Human fetal lung lysate
      Lane 3 : Human fetal liver lysate
      Lane 4 : Human kidney lysate
      Lane 5 : Human plasma lysate

      Lysates/proteins at 10 µg per lane.

      All lanes : Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size: 139 kDa


    ab124769 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Kein Problem! Das Angebot bleibt bestehen, egal, wie Sie sich entscheiden.

    Ich wünsche Ihnen viel Erfolg für Ihre Forschung!

    Vielleicht habe ich gute Nachrichten für Sie:

    Die Antwort vom Labor ist da: Das Immunogen für Factor H- Antikörper ab124769 ist zwischen Aminosäure 940 und 965 des humanen Factor H (SwissProt: P08603) lokalisiert.
    Read More

    Vielen Dank für Ihren Anruf.

    Wie versprochen habe ich fast alle unsere Factor H- Antikörper darauf geprüft, ob sie mit Schwein kreuzreagieren können. Das Beste, was an Sequenzähnlichkeit jedoch zu erhalten ist, sind 6...

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