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Anti-Factor IX/PTC antibody (ab128038)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor IX/PTC antibody (ab128038)

    Key features and details

    • Sheep polyclonal to Factor IX/PTC
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

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    Overview

    • Product name

      Anti-Factor IX/PTC antibody
      See all Factor IX/PTC primary antibodies
    • Description

      Sheep polyclonal to Factor IX/PTC
    • Host species

      Sheep
    • Specificity

      Recognizes human Factor IX/PTC as demonstrated by immunodiffusion. A single positive reactivity band was observed with Normal Human Plasma. No reaction was observed against Factor IX/PTC deficient plasma.

    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Full length native protein (purified) corresponding to Human Factor IX/PTC.

    • Positive control

      • Human Liver tissue
    • General notes

       This product was previously labelled as Factor IX

       

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
    • Storage buffer

      pH: 7.40
      Constituents: 0.24% HEPES, 0.58% Sodium chloride, 50% Glycerol
    • Concentration information loading...
    • Purity

      Ammonium Sulphate Precipitation
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Cardiovascular
      • Blood
      • Other
      • Cardiovascular
      • Blood
      • Coagulation
      • Intrinsic
      • Immunology
      • Innate Immunity
      • Complement
      • Classical Pathway

    Associated products

    • Isotype control

      • Sheep IgG - Isotype Control (ab37385)
    • Recombinant Protein

      • Recombinant Human Factor IX/PTC protein (ab158405)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab128038 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
    Notes
    IHC-P
    Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Function

      Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
    • Tissue specificity

      Synthesized primarily in the liver and secreted in plasma.
    • Involvement in disease

      Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
      Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
      Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis.
    • Sequence similarities

      Belongs to the peptidase S1 family.
      Contains 2 EGF-like domains.
      Contains 1 Gla (gamma-carboxy-glutamate) domain.
      Contains 1 peptidase S1 domain.
    • Domain

      Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.
    • Post-translational
      modifications

      Activated by factor XIa, which excises the activation peptide.
      The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession P00740 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 2158 Human
      • Omim: 300746 Human
      • SwissProt: P00740 Human
      • Unigene: 522798 Human
      • Alternative names

        • Christmas Disease antibody
        • Christmas factor antibody
        • Coagulant factor IX antibody
        • Coagulation factor 9 antibody
        • Coagulation factor IX antibody
        • Coagulation factor IXa heavy chain antibody
        • F9 antibody
        • FA9_HUMAN antibody
        • Factor 9 antibody
        • Factor IX Deficiency antibody
        • FactorIX antibody
        • FIX antibody
        • Haemophilia B antibody
        • HEMB antibody
        • MGC129641 antibody
        • MGC129642 antibody
        • P19 antibody
        • Plasma Thromboplastic Component antibody
        • Plasma thromboplastin component antibody
        • PTC antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor IX/PTC antibody (ab128038)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor IX/PTC antibody (ab128038)

        ab128038, at a concentration of 5 µg/ml, staining Factor IX/PTC in paraffin-embedded Human liver tissue by Immunohistochemistry.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab128038? Please let us know so that we can cite the reference in this datasheet.

      ab128038 has not yet been referenced specifically in any publications.

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