Overview

  • Product name

    Anti-Factor IX/PTC antibody
    See all Factor IX/PTC primary antibodies
  • Description

    Sheep polyclonal to Factor IX/PTC
  • Host species

    Sheep
  • Tested applications

    Suitable for: ELISA, IHC-P, Neutralisingmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length native protein (purified) corresponding to Human Factor IX/PTC.

  • Positive control

    • Human Liver tissue
  • General notes

     This product was previously labelled as Factor IX

     

Properties

Applications

Our Abpromise guarantee covers the use of ab128048 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
IHC-P Use a concentration of 2.5 µg/ml.
Neutralising Use at an assay dependent dilution. 60 Bethesda Units/ml IgG against normal plasma. One Bethesda unit/ml is defined as the amount of inhibitor that resulted in 50% residual F. IX activity after 2 hours at 37°C (Kasper CK et al, Thromb Diath Haemorrh 34:869, 1975).

Target

  • Function

    Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
  • Tissue specificity

    Synthesized primarily in the liver and secreted in plasma.
  • Involvement in disease

    Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
    Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
    Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis.
  • Sequence similarities

    Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • Domain

    Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.
  • Post-translational
    modifications

    Activated by factor XIa, which excises the activation peptide.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Christmas Disease antibody
    • Christmas factor antibody
    • Coagulant factor IX antibody
    • Coagulation factor 9 antibody
    • Coagulation factor IX antibody
    • Coagulation factor IXa heavy chain antibody
    • F9 antibody
    • FA9_HUMAN antibody
    • Factor 9 antibody
    • Factor IX Deficiency antibody
    • FactorIX antibody
    • FIX antibody
    • Haemophilia B antibody
    • HEMB antibody
    • MGC129641 antibody
    • MGC129642 antibody
    • P19 antibody
    • Plasma Thromboplastic Component antibody
    • Plasma thromboplastin component antibody
    • PTC antibody
    see all

Images

  • ab128048, at a concentration of 2.5 µg/ml, staining Factor IX/PTC in paraffin-embedded Human liver tissue by Immunohistochemistry.

References

ab128048 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

Thank you very much for your interest in ab128048.

To our knowledge, this product has not been tested in mouse. However by participating in our AbTrial program, you can now use our products in an untested application or species without financial risk.

Simply follow these easy steps below to take part in our AbTrial Program:

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3. Purchase and test the product at regular price.

4. https://www.abcam.com/abreviews with your results. Note your AbTrial discount code in the additional notes section.

5. Once the Abreview is submitted, the discount code will become active.

6. Apply your discount code on your next order to receive that value off.

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