Overview

  • Product name

    Anti-Factor IX/PTC antibody
    See all Factor IX/PTC primary antibodies
  • Description

    Rabbit polyclonal to Factor IX/PTC
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Factor IX/PTC aa 144-239.
    Database link: P00740

  • Positive control

    • IHC-P: Human liver and liver cancer tissue. ICC/IF: HeLa cells.
  • General notes

     This product was previously labelled as Factor IX

     

Properties

Applications

Our Abpromise guarantee covers the use of ab236279 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
ICC/IF 1/50 - 1/200.

Target

  • Function

    Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
  • Tissue specificity

    Synthesized primarily in the liver and secreted in plasma.
  • Involvement in disease

    Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
    Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
    Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis.
  • Sequence similarities

    Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • Domain

    Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.
  • Post-translational
    modifications

    Activated by factor XIa, which excises the activation peptide.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Christmas Disease antibody
    • Christmas factor antibody
    • Coagulant factor IX antibody
    • Coagulation factor 9 antibody
    • Coagulation factor IX antibody
    • Coagulation factor IXa heavy chain antibody
    • F9 antibody
    • FA9_HUMAN antibody
    • Factor 9 antibody
    • Factor IX Deficiency antibody
    • FactorIX antibody
    • FIX antibody
    • Haemophilia B antibody
    • HEMB antibody
    • MGC129641 antibody
    • MGC129642 antibody
    • P19 antibody
    • Plasma Thromboplastic Component antibody
    • Plasma thromboplastin component antibody
    • PTC antibody
    see all

Images

  • Paraffin-embedded human liver tissue stained for Factor IX/PTC using ab236279 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human liver cancer tissue stained for Factor IX/PTC using ab236279 at 1/100 dilution in immunohistochemical analysis.

  • HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for Factor IX/PTC (green) using ab236279 at 1/100 dilution in ICC/IF. Secondary antibody is Alexa Fluor® 488-congugated Goat Anti-Rabbit IgG (H+L).

References

ab236279 has not yet been referenced specifically in any publications.

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