Product nameAnti-Factor V antibody (Biotin)
See all Factor V primary antibodies
DescriptionRabbit polyclonal to Factor V (Biotin)
Tested applicationsSuitable for: RIA, IP, WB, ELISAmore details
Species reactivityReacts with: Human
Full length native Factor V purified from plasma (Human).
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
Constituents: 50% Glycerol, PBS, pH 7.5
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab48230 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|RIA||Use at an assay dependent dilution.|
|IP||Use at an assay dependent dilution.|
|WB||Use at an assay dependent dilution. Predicted molecular weight: 251 kDa.|
|ELISA||Use at an assay dependent dilution.|
FunctionCentral regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
Involvement in diseaseFactor V deficiency
Thrombophilia due to activated protein C resistance
Pregnancy loss, recurrent, 1
Sequence similaritiesBelongs to the multicopper oxidase family.
Contains 3 F5/8 type A domains.
Contains 2 F5/8 type C domains.
Contains 6 plastocyanin-like domains.
DomainDomain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
modificationsThrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
Activated protein C inactivates factor V and factor Va by proteolytic degradation.
Phosphorylation sites are present in the extracellular medium.
- Information by UniProt
- Activated protein C cofactor antibody
- APC cofactor antibody
- coagulation factor V (proaccelerin, labile factor) antibody
ab48230 has not yet been referenced specifically in any publications.