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Hi I am looking for at antibody able to neutralize factor VIII in rats, I was therefore wondering whether your anti-Factor VIII antibody (ab61370) reacts against rats as well?
Asked on Dec 01 2014
We have not previously used this antibody in rat and so we cannot guarantee that it will work.
I have compared the total homology with rat and there is 46% homology due to some parts of the protein being very well conserved and others which have diverged.
Unfortunately as the immunogen used is recombinant full length Human Factor VIII and that this antibody is a polyclonal antibody, we cannot determine which part of the protein the antibody will bind and this could also vary from lot to lot therefore we would not recommend ab61370 for use in rat.
Elisa ThomasAbcam Scientific Support
Answered on Dec 01 2014