Key features and details
- Sheep polyclonal to Factor X
- Suitable for: ELISA, IHC-P, Immunodiffusion, Immunoelectrophoresis
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Factor X antibody
See all Factor X primary antibodies
DescriptionSheep polyclonal to Factor X
Tested applicationsSuitable for: ELISA, IHC-P, Immunodiffusion, Immunoelectrophoresismore details
Species reactivityReacts with: Human
Predicted to work with: Macaque monkey
Full length native protein (purified) corresponding to Human Factor X.
- Human small intestine vessels, Human liver vessels.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.40
Constituents: 0.238% HEPES, 0.8766% Sodium chloride, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab110138 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use at an assay dependent dilution.|
|IHC-P||Use a concentration of 5 µg/ml.|
|Immunodiffusion||Use at an assay dependent dilution.|
|Immunoelectrophoresis||Use at an assay dependent dilution.|
FunctionFactor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Tissue specificityPlasma; synthesized in the liver.
Involvement in diseaseDefects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.
modificationsThe vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
- Information by UniProt
FormCleaved into the following 3 chains: 1. Factor X light chain 2. Factor X heavy chain 3. Activated factor Xa heavy chain
- Activated factor Xa heavy chain antibody
- Coagulation factor X antibody
- F10 antibody
ab110138 has been referenced in 1 publication.
- Tashiro H et al. Direct Factor X sequestration by systemic amyloid light-chain amyloidosis. Clin Case Rep 6:513-515 (2018). Human . PubMed: 29531730