Anti-Factor Xa Heavy Chain antibody (ab180701)

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Western blot - Anti-Factor Xa Heavy Chain antibody (ab180701)

    Key features and details

    • Rabbit polyclonal to Factor Xa Heavy Chain
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-Factor Xa Heavy Chain antibody
      See all Factor Xa Heavy Chain primary antibodies

    • Description

      Rabbit polyclonal to Factor Xa Heavy Chain

    • Host species

      Rabbit

    • Tested applications

      Suitable for: WBmore details

    • Species reactivity

      Reacts with: Human
      Predicted to work with: Rat

    • Immunogen

      Recombinant fragment corresponding to Human Factor Xa Heavy Chain aa 235-488.
      Sequence:

      IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF KVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITF RMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPY VDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVT GIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITS SPLK


      Database link: P00742
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • Positive control

      • HepG2 cell extract.

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab180701 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB
    1/500 - 1/2000. Predicted molecular weight: 55 kDa.
    Notes
    WB
    1/500 - 1/2000. Predicted molecular weight: 55 kDa.

    Target

    • Function

      Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

    • Tissue specificity

      Plasma; synthesized in the liver.

    • Involvement in disease

      Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.

    • Sequence similarities

      Belongs to the peptidase S1 family.
      Contains 2 EGF-like domains.
      Contains 1 Gla (gamma-carboxy-glutamate) domain.
      Contains 1 peptidase S1 domain.

    • Post-translational
      modifications

      The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
      N- and O-glycosylated.
      The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
      The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

    • Cellular localization

      Secreted.
    • Information by UniProt

    • Database links

      • Alternative names

        • Activated factor Xa heavy chain antibody
        • Coagulation factor X antibody
        • F10 antibody
        • FA10_HUMAN antibody
        • Factor X antibody
        • Factor X deficiency antibody
        • Factor Xa antibody
        • FX antibody
        • FXA antibody
        • Prothrombinase antibody
        • Stuart factor antibody
        • Stuart Prower factor antibody
        • Stuart-Prower factor antibody
        • Stuart-Prower factor deficiency antibody
        see all

      Images

      • Western blot - Anti-Factor Xa Heavy Chain antibody (ab180701)
        Western blot - Anti-Factor Xa Heavy Chain antibody (ab180701)
        Anti-Factor Xa Heavy Chain antibody (ab180701) at 1/500 dilution + HepG2 cell extract

        Predicted band size: 55 kDa

      References (0)

      Publishing research using ab180701? Please let us know so that we can cite the reference in this datasheet.

      ab180701 has not yet been referenced specifically in any publications.

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