Key features and details
- Rabbit polyclonal to Factor XIa (Biotin)
- Reacts with: Cow
- Conjugation: Biotin
- Isotype: IgG
Product nameAnti-Factor XIa antibody (Biotin)
See all Factor XIa primary antibodies
DescriptionRabbit polyclonal to Factor XIa (Biotin)
Species reactivityReacts with: Cow
Full length native protein Bovine FXIa purified from bovine plasma
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.50
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 50% Glycerol, PBS
Concentration information loading...
PurityProtein G purified
FunctionFactor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Tissue specificityIsoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
Involvement in diseaseDefects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
Sequence similaritiesBelongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain.
modificationsActivated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
- Information by UniProt
- coagulation factor XI antibody
- Coagulation factor XIa light chain antibody
- F11 antibody
ab100877 has not yet been referenced specifically in any publications.