Overview

  • Product name
    Anti-Factor XIIIa antibody
    See all Factor XIIIa primary antibodies
  • Description
    Rabbit polyclonal to Factor XIIIa
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow
  • Immunogen

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 228 of Human Factor XIIIa (NP_000120)

  • Positive control
    • H1299 whole cell lysate. Paraffin-embedded H520 xenograft. Paraformaldehyde-fixed A549 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab97636 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 83 kDa.
IHC-P 1/500 - 1/3000.
ICC/IF 1/100 - 1/200.

Target

  • Function
    Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
  • Involvement in disease
    Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
  • Sequence similarities
    Belongs to the transglutaminase superfamily. Transglutaminase family.
  • Post-translational
    modifications
    The activation peptide is released by thrombin.
  • Cellular localization
    Cytoplasm. Secreted. Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
  • Information by UniProt
  • Database links
    • Alternative names
      • bA525O21.1 (coagulation factor XIII, A1 polypeptide) antibody
      • Coagulation factor XIII A chain antibody
      • Coagulation factor XIII A1 polypeptide antibody
      • Coagulation factor XIII A1 subunit antibody
      • Coagulation factor XIII, A polypeptide antibody
      • Coagulation factor XIIIa antibody
      • F13A antibody
      • F13A_HUMAN antibody
      • F13a1 antibody
      • Factor XIIIA antibody
      • Fibrin stabilizing factor, A subunit antibody
      • Fibrinoligase antibody
      • FSF, A subunit antibody
      • Protein glutamine gamma glutamyltransferase A chain antibody
      • Protein-glutamine gamma-glutamyltransferase A chain antibody
      • TGase antibody
      • Transglutaminase A chain antibody
      • Transglutaminase, plasma antibody
      • Transglutaminase. plasma antibody
      see all

    Images

    • Western blot - Anti-Factor XIIIa antibody (ab97636)
      Western blot - Anti-Factor XIIIa antibody (ab97636)
      Anti-Factor XIIIa antibody (ab97636) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

      Predicted band size: 83 kDa



      7.5 % SDS PAGE
    • Immunocytochemistry/ Immunofluorescence - Anti-Factor XIIIa antibody (ab97636)
      Immunocytochemistry/ Immunofluorescence - Anti-Factor XIIIa antibody (ab97636)
      Immunofluorescence analysis of paraformaldehyde-fixed A549, using ab97636 at 1/200 dilution. Lower image is merged with DNA probe.
    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XIIIa antibody (ab97636)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XIIIa antibody (ab97636)
      Immunohistochemical analysis of paraffin-embedded H520 xenograft, using ab97636 at 1/500 dilution.

    References

    ab97636 has not yet been referenced specifically in any publications.

    Publishing research using ab97636? Please let us know so that we can cite the reference in this datasheet.

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