Key features and details
- FAK autophosphorylation inhibitor
- CAS Number: 4506-66-5
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameFAK Inhibitor 14, FAK autophosphorylation inhibitor
DescriptionFAK autophosphorylation inhibitor
Selective focal adhesion kinase (FAK) autophosphorylation inhibitor (IC50 = 1 μM). No significant activity at other kinases including EGFR, PDGFR and IGF-RI. Increases cell detachment and inhibits cell adhesion in cancer cells. Anticancer agent. Active in vivo and in vitro.
Also available in simple stock solutions (ab146739) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name1,2,4,5-Benzenetetramine tetrahydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144503 has been referenced in 1 publication.
- Tabdanov ED et al. Bimodal sensing of guidance cues in mechanically distinct microenvironments. Nat Commun 9:4891 (2018). PubMed: 30459308