Overview

  • Product name

    Anti-FAM120A/OSSA antibody
    See all FAM120A/OSSA primary antibodies
  • Description

    Rabbit polyclonal to FAM120A/OSSA
  • Host species

    Rabbit
  • Specificity

    ab106454 will not cross-react with FAM120B / PGCC1.
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human FAM120A/OSSA (internal sequence).
    Database link: NP_055427

  • Positive control

    • SK-N-SH cell lysate; Rat brain tissue.
  • General notes

     This product was previously labelled as FAM120A

     

Properties

Applications

Our Abpromise guarantee covers the use of ab106454 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 122 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • Function

    May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.
  • Tissue specificity

    Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level).
  • Sequence similarities

    Belongs to the constitutive coactivator of PPAR-gamma family.
  • Post-translational
    modifications

    Arg-982 is dimethylated, probably to asymmetric dimethylarginine.
    Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure.
  • Cellular localization

    Cytoplasm. Cell membrane. Translocates to plasma membrane upon ultraviolet exposure.
  • Information by UniProt
  • Database links

  • Alternative names

    • C9orf10 antibody
    • Chromosome 9 open reading frame 10 antibody
    • Constitutive coactivator of PPAR gamma like protein 1 antibody
    • Constitutive coactivator of PPAR-gamma-like protein 1 antibody
    • DNA polymerase transactivated protein 5 antibody
    • DNA polymerase transactivated protein 1 antibody
    • DNAPTP1 antibody
    • DNAPTP5 antibody
    • F120A_HUMAN antibody
    • FAM120A antibody
    • Family with sequence similarity 120A antibody
    • Hypothetical protein LOC23196 antibody
    • KIAA0183 antibody
    • LOC23196 antibody
    • MGC111527 antibody
    • MGC133257 antibody
    • OSSA antibody
    • Oxidative stress-associated Src activator antibody
    • Protein FAM120A antibody
    see all

Images

  • Lane 1 : Anti-FAM120A/OSSA antibody (ab106454) at 0.5 µg/ml
    Lane 2 : Anti-FAM120A/OSSA antibody (ab106454) at 1 µg/ml

    All lanes : SK-N-SH cell lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 122 kDa

  • ab106454, at 2.5µg/ml, staining FAM120A/OSSA in Rat brain tissue by Immunohistochemistry.

  • Immunofluorescence of FAM120A/OSSA in Rat Brain cells using ab106454 at 20 ug/ml.

References

This product has been referenced in:

  • Zheng G  et al. TMEM43-S358L mutation enhances NF-?B-TGFß signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Protein Cell N/A:N/A (2018). Read more (PubMed: 29980933) »
See 1 Publication for this product

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