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    fam120aossa-antibody-ab156695.pdf

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Signal Transduction Signaling Pathway Lipid Signaling Other
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Anti-FAM120A/OSSA antibody (ab156695)

  • Datasheet
Submit a review Submit a question References (1)

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Western blot - Anti-FAM120A/OSSA antibody (ab156695)
  • Immunoprecipitation - Anti-FAM120A/OSSA antibody (ab156695)

Key features and details

  • Rabbit polyclonal to FAM120A/OSSA
  • Suitable for: WB, IP
  • Reacts with: Mouse, Human
  • Isotype: IgG

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Overview

  • Product name

    Anti-FAM120A/OSSA antibody
    See all FAM120A/OSSA primary antibodies
  • Description

    Rabbit polyclonal to FAM120A/OSSA
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    IP
    Human
    WB
    Mouse
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide corresponding to Human FAM120A/OSSA aa 1068-1118.
    Database link: NP_055427.2

  • Positive control

    • 293T, Jurkat, NIH 3T3 and HeLa whole cell lysate (ab150035).
  • General notes

     This product was previously labelled as FAM120A

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    pH: 7
    Preservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate

    pH 7 to 8
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab156695 was affinity purified using an epitope specific to FAM120A/OSSA immobilized on solid support.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Signaling Pathway
    • Lipid Signaling
    • Other
    • Cell Biology
    • Other Antibodies
    • Other Antibodies

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HeLa whole cell lysate (ab150035)
    • HeLa whole cell lysate (ab29545)
    • NIH/3T3 whole cell lysate (ab7179)
    • Jurkat whole cell lysate (ab7899)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab156695 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IP
Human
WB
Mouse
Human
All applications
Rat
Rabbit
Guinea pig
Hamster
Chimpanzee
Macaque monkey
Rhesus monkey
Gorilla
Common marmoset
Orangutan
Elephant
Application Abreviews Notes
WB
1/500 - 1/2500. Predicted molecular weight: 121 kDa.
IP
Use at 2-10 µg/mg of lysate.
Notes
WB
1/500 - 1/2500. Predicted molecular weight: 121 kDa.
IP
Use at 2-10 µg/mg of lysate.

Target

  • Function

    May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.
  • Tissue specificity

    Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level).
  • Sequence similarities

    Belongs to the constitutive coactivator of PPAR-gamma family.
  • Post-translational
    modifications

    Arg-982 is dimethylated, probably to asymmetric dimethylarginine.
    Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure.
  • Cellular localization

    Cytoplasm. Cell membrane. Translocates to plasma membrane upon ultraviolet exposure.
  • Target information above from: UniProt accession Q9NZB2 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 100398882 Common marmoset
    • Entrez Gene: 23196 Human
    • Entrez Gene: 218236 Mouse
    • Entrez Gene: 291019 Rat
    • GenBank: NP_055427.2 Human
    • Omim: 612265 Human
    • SwissProt: Q9NZB2 Human
    • SwissProt: Q6A0A9 Mouse
    • Unigene: 372003 Human
    • Unigene: 707324 Human
    • Unigene: 426571 Mouse
    see all
  • Alternative names

    • C9orf10 antibody
    • Chromosome 9 open reading frame 10 antibody
    • Constitutive coactivator of PPAR gamma like protein 1 antibody
    • Constitutive coactivator of PPAR-gamma-like protein 1 antibody
    • DNA polymerase transactivated protein 5 antibody
    • DNA polymerase transactivated protein 1 antibody
    • DNAPTP1 antibody
    • DNAPTP5 antibody
    • F120A_HUMAN antibody
    • FAM120A antibody
    • Family with sequence similarity 120A antibody
    • Hypothetical protein LOC23196 antibody
    • KIAA0183 antibody
    • LOC23196 antibody
    • MGC111527 antibody
    • MGC133257 antibody
    • OSSA antibody
    • Oxidative stress-associated Src activator antibody
    • Protein FAM120A antibody
    see all

Images

  • Western blot - Anti-FAM120A/OSSA antibody (ab156695)
    Western blot - Anti-FAM120A/OSSA antibody (ab156695)
    All lanes : Anti-FAM120A/OSSA antibody (ab156695) at 1 µg/ml

    Lane 1 : Jurkat whole cell lysate at 50 µg
    Lane 2 : Jurkat whole cell lysate at 15 µg
    Lane 3 : HeLa whole cell lysate at 50 µg
    Lane 4 : 293T whole cell lysate at 50 µg
    Lane 5 : NIH 3T3 whole cell lysate at 50 µg

    Predicted band size: 121 kDa



    Detection: Chemiluminescence with an exposure time of 10 seconds.
  • Immunoprecipitation - Anti-FAM120A/OSSA antibody (ab156695)
    Immunoprecipitation - Anti-FAM120A/OSSA antibody (ab156695)

    Detection of FAM120A/OSSA by Western blot of immunoprecipitate.
    Immunoprecipitation of FAM120A/OSSA (6 µg of antibody per mg of Jurkat whole cell lysate; 1 mg/IP; 20% of IP loaded/lane), using the following:
    Lane 1: alternative rabbit anti-FAM120A/OSSA antibody
    Lane 2: ab156695
    Lane 3: Control IgG
    For the subsequent Western blot of immunoprecipitates, ab156695 was used at 1 µg/ml.
    Detection: Chemiluminescence with exposure time of 30 seconds.

Protocols

  • Western blot protocols
  • Immunoprecipitation protocols

Click here to view the general protocols

Datasheets and documents

    • Datasheet
  • References (1)

    Publishing research using ab156695? Please let us know so that we can cite the reference in this datasheet.

    ab156695 has been referenced in 1 publication.

    • Booy EP  et al. Comprehensive analysis of the BC200 ribonucleoprotein reveals a reciprocal regulatory function with CSDE1/UNR. Nucleic Acids Res 46:11575-11591 (2018). PubMed: 30247708

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