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    fam126a-antibody-ab241202.pdf

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Anti-FAM126A antibody (ab241202)

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Immunoprecipitation - Anti-FAM126A antibody (ab241202)

    Key features and details

    • Rabbit polyclonal to FAM126A
    • Suitable for: IP
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-FAM126A antibody
      See all FAM126A primary antibodies
    • Description

      Rabbit polyclonal to FAM126A
    • Host species

      Rabbit
    • Tested applications

      Suitable for: IPmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse
    • Immunogen

      Synthetic peptide within Human FAM126A aa 400-450. The exact sequence is proprietary.
      Database link: Q9BYI3

    • Positive control

      • IP: HeLa whole cell lysate.
    • General notes

      ab241202 has not performed satisfactorily when used for WB of FAM126A in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of FAM126A.

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 6.8
      Preservative: 0.09% Sodium azide
      Constituents: Tris buffered saline, 0.1% BSA
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Purification notes

      Antibody was affinity purified using an epitope specific to FAM126A immobilized on solid support.
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Neuroscience
      • Neurology process
      • Neural Signal Transduction
      • Neuroscience
      • Neurology process
      • Neurogenesis
      • Developmental Biology
      • Organogenesis
      • Nervous system development

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Positive Controls

      • HeLa whole cell lysate (ab150035)
      • HeLa whole cell lysate (ab29545)

    Applications

    Our Abpromise guarantee covers the use of ab241202 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IP Use at an assay dependent concentration.

    8 - 15 µl/mg lysate

    Target

    • Function

      Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway.
    • Tissue specificity

      Widely expressed. Highest levels in heart, brain, placenta, spleen and testis.
    • Involvement in disease

      Leukodystrophy, hypomyelinating, 5
    • Sequence similarities

      Belongs to the FAM126 family.
    • Cellular localization

      Cytoplasm, cytosol. Cell membrane. Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex.
    • Target information above from: UniProt accession Q9BYI3 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 84668 Human
      • Entrez Gene: 84652 Mouse
      • Omim: 610531 Human
      • SwissProt: Q9BYI3 Human
      • SwissProt: Q6P9N1 Mouse
      • Unigene: 85603 Human
      • Unigene: 304976 Mouse
      • Unigene: 486278 Mouse
      • Alternative names

        • Down regulated by Ctnnb1 a antibody
        • Down regulated by CTNNB1 protein A antibody
        • Down-regulated by CTNNB1 protein A antibody
        • DRCTNNB1A antibody
        • FAM126A antibody
        • Family with sequence similarity 126 member A antibody
        • HCC antibody
        • HLD5 antibody
        • HYCC1 antibody
        • HYCCI_HUMAN antibody
        • Hyccin antibody
        • Protein FAM126A antibody
        see all

      Images

      • Immunoprecipitation - Anti-FAM126A antibody (ab241202)
        Immunoprecipitation - Anti-FAM126A antibody (ab241202)

        FAN126A was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab241202 at 8 µl/reaction. Western blot was performed from the immunoprecipitate using ab241202 at 1/400 dilution.

        Lane 1: ab241202 IP in HeLa whole cell lysate.
        Lane 2: Control IgG IP in HeLa whole cell lysate.

        Detection: Chemiluminescence with exposure time of 3 minutes.

        Lysates prepared in NETN buffer.

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab241202? Please let us know so that we can cite the reference in this datasheet.

      ab241202 has not yet been referenced specifically in any publications.

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