Key features and details
- Rabbit polyclonal to FAM126A
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-FAM126A antibody
See all FAM126A primary antibodies
DescriptionRabbit polyclonal to FAM126A
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Recombinant protein fragment corresponding to a region within amino acids 178 and 416 of Human FAM126A (NP_115970).
- 293T, A431, H1299 ,HeLa, HepG2, MOLT4 and Raji cell lysates
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab98144 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 58 kDa.|
FunctionComponent of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway.
Tissue specificityWidely expressed. Highest levels in heart, brain, placenta, spleen and testis.
Involvement in diseaseLeukodystrophy, hypomyelinating, 5
Sequence similaritiesBelongs to the FAM126 family.
Cellular localizationCytoplasm, cytosol. Cell membrane. Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex.
- Information by UniProt
- Down regulated by Ctnnb1 a antibody
- Down regulated by CTNNB1 protein A antibody
- Down-regulated by CTNNB1 protein A antibody
ab98144 has not yet been referenced specifically in any publications.