Recombinant
RabMAb

Recombinant Anti-FAM134B antibody [EPR10608(B)] (ab151755)

Overview

  • Product name

    Anti-FAM134B antibody [EPR10608(B)]
    See all FAM134B primary antibodies
  • Description

    Rabbit monoclonal [EPR10608(B)] to FAM134B
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human FAM134B (UniProt ID: Q9H6L5).

  • Positive control

    • Human cerebellum lysate; fetal brain lysate.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20ºC.
  • Storage buffer

    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR10608(B)
  • Isotype

    IgG

Applications

Our Abpromise guarantee covers the use of ab151755 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 54 kDa.
  • Application notes
    Is unsuitable for ICC,IHC-P or IP.
  • Target

    • Function

      Required for long-term survival of nociceptive and autonomic ganglion neurons.
    • Involvement in disease

      Defects in FAM134B are the cause of hereditary sensory and autonomic neuropathy type 2B (HSAN2B) [MIM:613115]. A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2B is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation. Onset occurs in the first or second decade, with impaired nociception and progressive mutilating ulceration of the hands and feet with osteomyelitis and acroosteolysis. Amputations of the hands and feet are common. Autonomic dysfunction includes hyperhidrosis, urinary incontinence, and slow pupillary light response.
    • Sequence similarities

      Belongs to the FAM134 family.
    • Cellular localization

      Golgi apparatus > cis-Golgi network membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • F134B_HUMAN antibody
      • FAM134B antibody
      • family with sequence similarity 134 member B antibody
      • HSAN2B antibody
      • JK 1 antibody
      • JK1 antibody
      • Protein FAM134B antibody
      see all

    Images

    • All lanes : Anti-FAM134B antibody [EPR10608(B)] (ab151755) at 1/1000 dilution

      Lane 1 : Fetal brain cell lysate
      Lane 2 : Human cerebellum cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Standard HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 54 kDa

    • All lanes : Anti-FAM134B antibody [EPR10608(B)] (ab151755) at 1/5000 dilution

      Lane 1 : Mouse brain tissue lysates
      Lane 2 : Rat brain tissue lysates

      Lysates/proteins at 20 µg per lane.

      Secondary
      All lanes : Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/20000 dilution

      Predicted band size: 54 kDa
      Observed band size: 54 kDa


      Exposure time: 3 minutes


      Blocking and diluting buffer: 5% NFDM/TBST

    References

    This product has been referenced in:

    • Hu X  et al. MicroRNA-186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1. Exp Ther Med 17:1930-1938 (2019). Read more (PubMed: 30867688) »
    • Xu ZM  et al. Ginsenoside Rg1 Prevents Doxorubicin-Induced Cardiotoxicity through the Inhibition of Autophagy and Endoplasmic Reticulum Stress in Mice. Int J Mol Sci 19:N/A (2018). Read more (PubMed: 30463294) »
    See all 3 Publications for this product

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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