Product nameAnti-FAM134B antibody [EPR10608(B)]
See all FAM134B primary antibodies
DescriptionRabbit monoclonal [EPR10608(B)] to FAM134B
Tested applicationsSuitable for: WBmore details
Unsuitable for: ICC,IHC-P or IP
Species reactivityReacts with: Mouse, Rat, Human
A synthetic peptide corresponding to residues in Human FAM134B (UniProt ID: Q9H6L5).
- Human cerebellum lysate; fetal brain lysate.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferPreservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
Concentration information loading...
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab151755 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000 - 1/10000. Predicted molecular weight: 54 kDa.|
FunctionRequired for long-term survival of nociceptive and autonomic ganglion neurons.
Involvement in diseaseDefects in FAM134B are the cause of hereditary sensory and autonomic neuropathy type 2B (HSAN2B) [MIM:613115]. A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2B is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation. Onset occurs in the first or second decade, with impaired nociception and progressive mutilating ulceration of the hands and feet with osteomyelitis and acroosteolysis. Amputations of the hands and feet are common. Autonomic dysfunction includes hyperhidrosis, urinary incontinence, and slow pupillary light response.
Sequence similaritiesBelongs to the FAM134 family.
Cellular localizationGolgi apparatus > cis-Golgi network membrane.
- Information by UniProt
- F134B_HUMAN antibody
- FAM134B antibody
- family with sequence similarity 134 member B antibody
All lanes : Anti-FAM134B antibody [EPR10608(B)] (ab151755) at 1/1000 dilution
Lane 1 : Fetal brain cell lysate
Lane 2 : Human cerebellum cell lysate
Lysates/proteins at 10 µg per lane.
All lanes : Standard HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 54 kDa
All lanes : Anti-FAM134B antibody [EPR10608(B)] (ab151755) at 1/5000 dilution
Lane 1 : Mouse brain tissue lysates
Lane 2 : Rat brain tissue lysates
Lysates/proteins at 20 µg per lane.
All lanes : Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/20000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
Exposure time: 3 minutes
Blocking and diluting buffer: 5% NFDM/TBST
This product has been referenced in:
- Hu X et al. MicroRNA-186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1. Exp Ther Med 17:1930-1938 (2019). Read more (PubMed: 30867688) »
- Viswanath P et al. 2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas. Cancer Res 78:2290-2304 (2018). Read more (PubMed: 29358170) »