Anti-FAM38A/PIEZO1 antibody (ab128245)
Key features and details
- Rabbit polyclonal to FAM38A/PIEZO1
- Suitable for: ELISA, WB
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
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- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-FAM38A/PIEZO1 antibody
See all FAM38A/PIEZO1 primary antibodies -
Description
Rabbit polyclonal to FAM38A/PIEZO1 -
Host species
Rabbit -
Tested applications
Suitable for: ELISA, WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Rabbit -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. -
Storage buffer
Constituents: 1.21% Tris, 0.75% Glycine, 2% Sucrose -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab128245 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ELISA |
Use at an assay dependent concentration.
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WB | (2) |
1/500 - 1/2000.
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Notes |
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ELISA
Use at an assay dependent concentration. |
WB
1/500 - 1/2000. |
Target
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Function
Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. -
Tissue specificity
Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. -
Sequence similarities
Belongs to the PIEZO family. -
Cellular localization
Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 9780 Human
- Entrez Gene: 234839 Mouse
- Entrez Gene: 361430 Rat
- Omim: 611184 Human
- SwissProt: Q92508 Human
- SwissProt: E2JF22 Mouse
- SwissProt: Q0KL00 Rat
- Unigene: 377001 Human
see all -
Alternative names
- DHS antibody
- Fam38a antibody
- Family with sequence similarity 38 member A antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (15)
ab128245 has been referenced in 15 publications.
- Wu Y et al. A Pancancer Study of PIEZO1 as a Prognosis and Immune Biomarker of Human Tumors. J Oncol 2022:6725570 (2022). PubMed: 35747124
- He J et al. Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1. Cell Death Dis 12:226 (2021). PubMed: 33649312
- Wang W et al. LncRNA FAM83A-AS1 promotes lung adenocarcinoma progression by enhancing the pre-mRNA stability of FAM83A. Thorac Cancer 12:1495-1502 (2021). PubMed: 33687144
- Zhou J et al. The Degradation of Airway Epithelial Tight Junctions in Asthma Under High Airway Pressure Is Probably Mediated by Piezo-1. Front Physiol 12:637790 (2021). PubMed: 33868003
- Huang JQ et al. Mechanically Activated Calcium Channel PIEZO1 Modulates Radiation-Induced Epithelial-Mesenchymal Transition by Forming a Positive Feedback With TGF-β1. Front Mol Biosci 8:725275 (2021). PubMed: 34722630