Key features and details
- Rabbit polyclonal to FANCG
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-FANCG antibody
See all FANCG primary antibodies
DescriptionRabbit polyclonal to FANCG
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
- Recombinant Human FANCG protein (ab114925) can be used as a positive control in WB.
General notesAvoid cycles of freezing and thawing. Expiration date is one (1) year from date of opening.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 0.424% Potassium phosphate, 0.878% Sodium chloride
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab5067 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500. Detects a band of approximately 69 kDa (predicted molecular weight: 69 kDa).|
FunctionDNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
Tissue specificityHighly expressed in testis and thymus. Found in lymphoblasts.
Involvement in diseaseDefects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
Sequence similaritiesContains 4 TPR repeats.
Cellular localizationNucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
- Information by UniProt
- DNA repair protein XRCC9 antibody
- FAG antibody
- FANCG antibody
Anti-FANCG antibody (ab5067) at 1/500 dilution + HeLa whole cell lysate at 35 µg
IRDye 800 conjugated Goat anti-Rabbit IgG [H&L] at 1/10000 dilution
Performed under reducing conditions.
Predicted band size: 69 kDa
Observed band size: 69 kDa
Additional bands at: 11 kDa, 24 kDa. We are unsure as to the identity of these extra bands.
ab5067 has been referenced in 2 publications.
- Gonsalvez DG et al. Imaging and Quantification of Myelin Integrity After Injury With Spectral Confocal Reflectance Microscopy. Front Mol Neurosci 12:275 (2019). PubMed: 31803018
- Song ZP et al. Minocycline attenuates bone cancer pain in rats by inhibiting NF-?B in spinal astrocytes. Acta Pharmacol Sin 37:753-62 (2016). PubMed: 27157092