Overview

  • Product name

  • Description

    Goat polyclonal to Fascin 2
  • Host species

    Goat
  • Specificity

    ab78599 is expected to recognize both reported isoforms (NP_001070650.1 and NP_036550.1) of Fascin 2.
  • Tested applications

    Suitable for: IHC (PFA fixed)more details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat, Cow, Dog, Human
  • Immunogen

    Synthetic peptide corresponding to Human Fascin 2 (internal sequence). (NP_001070650.1 and NP_036550.1)
    Sequence:

    CHHRGSNQLDTNR

  • Positive control

    • IHC: Mouch cochlea tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab78599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC (PFA fixed) Use at an assay dependent concentration.

Target

  • Function

    Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
  • Tissue specificity

    Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.
  • Involvement in disease

    Defects in FSCN2 are the cause of retinitis pigmentosa type 30 (RP30) [MIM:607921]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP30 inheritance is autosomal dominant.
  • Sequence similarities

    Belongs to the fascin family.
  • Cellular localization

    Cytoplasm > cytoskeleton. Cell projection > stereocilium.
  • Information by UniProt
  • Database links

  • Alternative names

    • Fascin homolog 2, actin bundling protein, retinal Strongylocentrotus purpuratus antibody
    • Fascin Strongylocentrotus purpuratus homolog 2 actin bundling protein, retinal antibody
    • Fascin-2 antibody
    • FSCN2 antibody
    • FSCN2_HUMAN antibody
    • Retinal fascin antibody
    • RFSN antibody
    • RP30 antibody
    see all

References

This product has been referenced in:

  • Liu X  et al. Null Mutation of the Fascin2 Gene by TALEN Leading to Progressive Hearing Loss and Retinal Degeneration in C57BL/6J Mice. G3 (Bethesda) 8:3221-3230 (2018). Read more (PubMed: 30082328) »
  • Sui X  et al. p53 controls colorectal cancer cell invasion by inhibiting the NF-?B-mediated activation of Fascin. Oncotarget 6:22869-79 (2015). Read more (PubMed: 26362504) »
See all 2 Publications for this product

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