• Product name

  • Description

    Rabbit polyclonal to FAT/FAT1
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Dog
  • Immunogen

    Synthetic peptide within Human FAT/FAT1 aa 4450-4500. The exact sequence is proprietary. NP_005236.2


    Database link: Q14517

  • Positive control

    • HeLa, 293T, Jurkat, NIH 3T3 and TCMK-1 whole cell lysates
  • General notes

     This product was previously labelled as FAT




Our Abpromise guarantee covers the use of ab190242 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 506 kDa.


  • Function

    Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
  • Tissue specificity

    Expressed in many epithelial and some endothelial and smooth muscle cells.
  • Sequence similarities

    Contains 33 cadherin domains.
    Contains 5 EGF-like domains.
    Contains 1 laminin G-like domain.
  • Domain

    A PTB-like motif (DNXYH sequence) is required for the targeting to the leading edge. This motif represents a minimal protein-protein interaction core motif that is not regulated by tyrosine phosphorylation.
  • Post-translational

    Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.
  • Cellular localization

    Cell membrane. Nucleus. Cytoplasm > perinuclear region.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cadherin family member 7 antibody
    • Cadherin family member 7 precursor antibody
    • Cadherin ME5 antibody
    • Cadherin related tumor suppressor antibody
    • Cadherin related tumor suppressor homolog antibody
    • Cadherin related tumor suppressor homolog precursor antibody
    • Cadherin related tumor suppressor homolog precursor (FAT protein homolog) antibody
    • Cadherin-related tumor suppressor homolog antibody
    • CDHF 7 antibody
    • CDHF7 antibody
    • FAT 1 antibody
    • FAT tumor suppressor 1 antibody
    • FAT tumor suppressor homolog 1 antibody
    • FAT1 antibody
    • FAT1_HUMAN antibody
    • hFat 1 antibody
    • hFAT antibody
    • hFat1 antibody
    • Homolog of Drosophila FAT protein antibody
    • Homolog of Drosophila FAT protein precursor antibody
    • Homolog of Drosophila tumor suppressor FAT precursor antibody
    • ME 5 antibody
    • ME5 antibody
    • nuclear form antibody
    • Protein fat homolog antibody
    • Protocadherin Fat 1 antibody
    see all


  • All lanes : Anti-FAT/FAT1 antibody (ab190242) at 0.1 µg/ml

    Lane 1 : HeLa whole cell lysate
    Lane 2 : 293T whole cell lysate
    Lane 3 : Jurkat whole cell lysate
    Lane 4 : TCMK-1 whole cell lysate
    Lane 5 : NIH 3T3 whole cell lysate

    Lysates/proteins at 50 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 506 kDa

    Exposure time: 3 minutes


This product has been referenced in:

  • Lahrouchi N  et al. Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly. Nat Commun 10:1180 (2019). Read more (PubMed: 30862798) »
  • Hu X  et al. FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma. Oncol Rep 39:2136-2146 (2018). Read more (PubMed: 29565465) »
See all 2 Publications for this product

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