Overview

  • Product name

  • Description

    Rabbit polyclonal to FAT/FAT1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human FAT/FAT1 (internal sequence). Gene Accession: NP_005236.
    Database link: Q14517

  • Positive control

    • Human thyroid cancer tissue.
  • General notes

     This product was previously labelled as FAT

     

Properties

Applications

Our Abpromise guarantee covers the use of ab198892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.

Target

  • Function

    Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
  • Tissue specificity

    Expressed in many epithelial and some endothelial and smooth muscle cells.
  • Sequence similarities

    Contains 33 cadherin domains.
    Contains 5 EGF-like domains.
    Contains 1 laminin G-like domain.
  • Domain

    A PTB-like motif (DNXYH sequence) is required for the targeting to the leading edge. This motif represents a minimal protein-protein interaction core motif that is not regulated by tyrosine phosphorylation.
  • Post-translational
    modifications

    Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.
  • Cellular localization

    Cell membrane. Nucleus. Cytoplasm > perinuclear region.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cadherin family member 7 antibody
    • Cadherin family member 7 precursor antibody
    • Cadherin ME5 antibody
    • Cadherin related tumor suppressor antibody
    • Cadherin related tumor suppressor homolog antibody
    • Cadherin related tumor suppressor homolog precursor antibody
    • Cadherin related tumor suppressor homolog precursor (FAT protein homolog) antibody
    • Cadherin-related tumor suppressor homolog antibody
    • CDHF 7 antibody
    • CDHF7 antibody
    • FAT 1 antibody
    • FAT tumor suppressor 1 antibody
    • FAT tumor suppressor homolog 1 antibody
    • FAT1 antibody
    • FAT1_HUMAN antibody
    • hFat 1 antibody
    • hFAT antibody
    • hFat1 antibody
    • Homolog of Drosophila FAT protein antibody
    • Homolog of Drosophila FAT protein precursor antibody
    • Homolog of Drosophila tumor suppressor FAT precursor antibody
    • ME 5 antibody
    • ME5 antibody
    • nuclear form antibody
    • Protein fat homolog antibody
    • Protocadherin Fat 1 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling FAT/FAT1 with ab198892 at 1/40 dilution.

References

ab198892 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Application
Immunocytochemistry/ Immunofluorescence
Sample
Mouse Cell (Primary chondrocytes)
Permeabilization
Yes - 0.1% Triton X-100 in PBS
Specification
Primary chondrocytes
Blocking step
Serum as blocking agent for 30 minute(s) · Concentration: 10% · Temperature: 23°C
Fixative
Paraformaldehyde

Mr. Masato Nomura

Verified customer

Submitted Jan 19 2018

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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