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ab22759 has been referenced in 39 publications.

  • Zhao X  et al. Osthole inhibits oleic acid/lipopolysaccharide-induced lipid accumulation and inflammatory response through activating PPARa signaling pathway in cultured hepatocytes. Exp Gerontol 119:7-13 (2019). PubMed: 30659956
  • Rajagopal R  et al. Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision. JCI Insight 3:N/A (2018). PubMed: 29321376
  • Kapadia B  et al. Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL. Nat Commun 9:829 (2018). PubMed: 29483509
  • Montani L  et al. De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination. J Cell Biol 217:1353-1368 (2018). PubMed: 29434029
  • Gao XL  et al. Upregulation of microRNA-335-5p reduces inflammatory responses by inhibiting FASN through the activation of AMPK/ULK1 signaling pathway in a septic mouse model. Cytokine 110:466-478 (2018). PubMed: 29866515
  • Dihingia A  et al. Hexane-Isopropanolic Extract of Tungrymbai, a North-East Indian fermented soybean food prevents hepatic steatosis via regulating AMPK-mediated SREBP/FAS/ACC/HMGCR and PPARa/CPT1A/UCP2 pathways. Sci Rep 8:10021 (2018). PubMed: 29968750
  • Pan BL  et al. Effects of MicroRNA-206 on Osteosarcoma Cell Proliferation, Apoptosis, Migration and Invasion by Targeting ANXA2 Through the AKT Signaling Pathway. Cell Physiol Biochem 45:1410-1422 (2018). PubMed: 29462818
  • Song J  et al. Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis. Nat Commun 9:3427 (2018). PubMed: 30143643
  • Gao X  et al. Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway. J Transl Med 16:319 (2018). PubMed: 30458883
  • Rodríguez-Blanco G  et al. Tissue proteomics outlines AGR2 AND LOX5 as markers for biochemical recurrence of prostate cancer. Oncotarget 9:36444-36456 (2018). PubMed: 30559929
  • Zhou Y  et al. Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts. J Exp Clin Cancer Res 37:324 (2018). PubMed: 30591064
  • Xu M  et al. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun 8:15397 (2017). Mouse . PubMed: 28589954
  • Stein S  et al. Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. J Clin Invest 127:583-592 (2017). PubMed: 28094767
  • Hong SH  et al. Effects of ingredients of Korean brown rice cookies on attenuation of cholesterol level and oxidative stress in high-fat diet-fed mice. Nutr Res Pract 11:365-372 (2017). PubMed: 28989572
  • Choi MS  et al. S-nitrosylation of fatty acid synthase regulates its activity through dimerization. J Lipid Res 57:607-15 (2016). PubMed: 26851298
  • Jia L  et al. Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity. Sci Rep 6:36209 (2016). PubMed: 27824080
  • Nieminen P  et al. De novo lipogenesis is suppressed during fasting but upregulated at population decline in cyclic voles. Exp Biol Med (Maywood) 241:882-7 (2016). PubMed: 26892709
  • Karantanos T  et al. Caveolin-1 regulates hormone resistance through lipid synthesis, creating novel therapeutic opportunities for castration-resistant prostate cancer. Oncotarget 7:46321-46334 (2016). PubMed: 27331874
  • Sun X  et al. Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation. J Biol Chem 291:1115-22 (2016). WB . PubMed: 26511317
  • Sawano T  et al. Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan. Oncol Rep 33:2151-60 (2015). IHC . PubMed: 25708528
  • Southam AD  et al. Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids. Cancer Res 75:2530-40 (2015). PubMed: 25943877
  • Rolyan H  et al. Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression. J Neurosci 35:12002-17 (2015). Mouse . PubMed: 26311780
  • Li J  et al. Fatty acid synthase mediates the epithelial-mesenchymal transition of breast cancer cells. Int J Biol Sci 10:171-80 (2014). WB ; Human . PubMed: 24520215
  • Greseth MD & Traktman P De novo fatty acid biosynthesis contributes significantly to establishment of a bioenergetically favorable environment for vaccinia virus infection. PLoS Pathog 10:e1004021 (2014). ICC/IF ; African green monkey . PubMed: 24651651
  • Tang WC  et al. Rab18 facilitates dengue virus infection by targeting Fatty Acid synthase to sites of viral replication. J Virol 88:6793-804 (2014). PubMed: 24696471
  • Gori M  et al. Protective effect of the Y220C mutant p53 against steatosis: good news? J Cell Physiol 229:1182-92 (2014). Human . PubMed: 24395441
  • Impheng H  et al. The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells. PLoS One 9:e107842 (2014). PubMed: 25255125
  • Al-Dwairi A  et al. Enhanced gastrointestinal expression of cytosolic malic enzyme (ME1) induces intestinal and liver lipogenic gene expression and intestinal cell proliferation in mice. PLoS One 9:e113058 (2014). WB ; Mouse . PubMed: 25402228
  • Funai K  et al. Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. J Clin Invest 123:1229-40 (2013). IP ; Mouse . PubMed: 23376793
  • Jensen-Urstad AP  et al. Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARa. J Lipid Res 54:1848-59 (2013). PubMed: 23585690
  • Boucher J  et al. Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling. Nat Commun 3:902 (2012). WB . PubMed: 22692545
  • Chen Z  et al. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor ?-sparing thiazolidinedione. J Biol Chem 287:23537-48 (2012). WB ; Mouse . PubMed: 22621923
  • Razani B  et al. Fatty Acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem 286:30949-61 (2011). WB ; Mouse . PubMed: 21757749
  • Rivas DA  et al. Lipogenic regulators are elevated with age and chronic overload in rat skeletal muscle. Acta Physiol (Oxf) 202:691-701 (2011). PubMed: 21439027
  • Wei X  et al. De Novo Lipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation. J Biol Chem 286:2933-45 (2011). WB, ICC/IF, IP ; Human, Mouse . PubMed: 21098489
  • Chang NW  et al. Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model. Biochim Biophys Acta 1812:558-64 (2011). PubMed: 21081159
  • Su Y  et al. Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes. J Nutr 139:945-51 (2009). WB ; Rat . PubMed: 19321580
  • Xiao R  et al. Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. Am J Physiol Gastrointest Liver Physiol 294:G868-76 (2008). PubMed: 18239060
  • Bezy O  et al. TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity. Mol Cell Biol 27:6818-31 (2007). WB ; Mouse . PubMed: 17646392

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