Anti-FBXO11 antibody (ab181801)
Key features and details
- Rabbit polyclonal to FBXO11
- Suitable for: WB, ICC
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-FBXO11 antibody -
Description
Rabbit polyclonal to FBXO11 -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICCmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide within Human FBXO11 (internal sequence). The exact sequence is proprietary.
Database link: Q86XK2 -
Positive control
- HeLa cells and cell lysate,
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Constituents: 1.21% Tris, 0.75% Glycine, 2% Sucrose -
Concentration information loading...
-
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab181801 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/50 - 1/2000. Predicted molecular weight: 104 kDa.
|
|
ICC |
Use a concentration of 5 µg/ml.
|
Notes |
---|
WB
1/50 - 1/2000. Predicted molecular weight: 104 kDa. |
ICC
Use a concentration of 5 µg/ml. |
Target
-
Function
Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53. -
Tissue specificity
Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes. -
Pathway
Protein modification; protein ubiquitination. -
Sequence similarities
Contains 1 F-box domain.
Contains 19 PbH1 repeats.
Contains 1 UBR-type zinc finger. -
Cellular localization
Nucleus. - Information by UniProt
-
Database links
- Entrez Gene: 80204 Human
- Entrez Gene: 225055 Mouse
- Entrez Gene: 301674 Rat
- Omim: 607871 Human
- SwissProt: Q86XK2 Human
- SwissProt: Q7TPD1 Mouse
- SwissProt: Q7TSL3 Rat
- Unigene: 352677 Human
see all -
Alternative names
- F box only protein 11 antibody
- F box protein 11 antibody
- F-box only protein 11 antibody
see all
Images
Protocols
Datasheets and documents
-
SDS download
-
Datasheet download
References (6)
ab181801 has been referenced in 6 publications.
- Wen X et al. miR-181a-5p inhibits the proliferation and invasion of drug-resistant glioblastoma cells by targeting F-box protein 11 expression. Oncol Lett 20:235 (2020). PubMed: 32968457
- Wang Z et al. Long Non-Coding RNA GATA6-AS1 Sponges miR-324-5p to Inhibit Lung Cancer Cell Proliferation and Invasion. Onco Targets Ther 13:9741-9751 (2020). PubMed: 33061453
- Zhang Y et al. LINC01436, regulating miR-585 and FBXO11, is an oncogenic lncRNA in the progression of gastric cancer. Cell Biol Int 44:882-893 (2020). PubMed: 31829474
- Xu Q et al. miR-376a inhibits the proliferation and invasion of osteosarcoma by targeting FBXO11. Hum Cell 32:390-396 (2019). PubMed: 31079326
- Ma Y et al. The tumor suppressive miR-26a regulation of FBXO11 inhibits proliferation, migration and invasion of hepatocellular carcinoma cells. Biomed Pharmacother 101:648-655 (2018). WB . PubMed: 29518611
- Zhang Y et al. Downregulated miR-621 promotes cell proliferation via targeting CAPRIN1 in hepatocellular carcinoma. Am J Cancer Res 8:2116-2129 (2018). PubMed: 30416861