Overview

  • Product name

  • Description

    Rabbit polyclonal to FBXO11
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICCmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human FBXO11 (internal sequence). The exact sequence is proprietary.
    Database link: Q86XK2

  • Positive control

    • HeLa cells and cell lysate,

Properties

Applications

Our Abpromise guarantee covers the use of ab181801 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/2000. Predicted molecular weight: 104 kDa.
ICC Use a concentration of 5 µg/ml.

Target

  • Function

    Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53.
  • Tissue specificity

    Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Contains 1 F-box domain.
    Contains 19 PbH1 repeats.
    Contains 1 UBR-type zinc finger.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • F box only protein 11 antibody
    • F box protein 11 antibody
    • F-box only protein 11 antibody
    • FBX11 antibody
    • FBX11_HUMAN antibody
    • Fbxo11 antibody
    • PRMT9 antibody
    • Protein arginine N methyltransferase 9 antibody
    • Ubiquitin protein ligase E3 component n recognin 6 antibody
    • UBR6 antibody
    • UG063H01 antibody
    • VIT 1 antibody
    • VIT-1 antibody
    • VIT1 antibody
    • Vitiligo associated protein 1 antibody
    • Vitiligo associated protein VIT 1 antibody
    • Vitiligo-associated protein 1 antibody
    see all

Images

  • Immunocytochemistry analysis of HeLa cells labeling FBXO11 with ab181801 at 5 µg/ml

  • All lanes : Anti-FBXO11 antibody (ab181801) at 1/500 dilution

    Lane 1 : HeLa cell lysate at 25 µg
    Lane 2 : HeLa cell lysate at 15 µg
    Lane 3 : HeLa cell lysate at 7 µg

    Predicted band size: 104 kDa

References

This product has been referenced in:

  • Ma Y  et al. The tumor suppressive miR-26a regulation of FBXO11 inhibits proliferation, migration and invasion of hepatocellular carcinoma cells. Biomed Pharmacother 101:648-655 (2018). WB . Read more (PubMed: 29518611) »
  • Zhang Y  et al. Downregulated miR-621 promotes cell proliferation via targeting CAPRIN1 in hepatocellular carcinoma. Am J Cancer Res 8:2116-2129 (2018). Read more (PubMed: 30416861) »
See all 2 Publications for this product

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There are currently no Customer reviews or Questions for ab181801.
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