• Product name
    Anti-FBXO2 antibody [EPR7328(2)]
    See all FBXO2 primary antibodies
  • Description
    Rabbit monoclonal [EPR7328(2)] to FBXO2
  • Host species
  • Tested applications
    Suitable for: WB, Flow Cytmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to a region within Human FBXO2 (Q9UK22).

  • Positive control
    • Human fetal brain lysate, NIH/3T3 cells and cell lysate, Neuro2a cell lysate, Human fetal lung lysate, HT29 cell lysate, U87 MG cell lysate.
  • General notes



    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab133717 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Detects a band of approximately 33 kDa (predicted molecular weight: 33 kDa).
Flow Cyt 1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.


  • Application notes
    Is unsuitable for ICC,IHC-P or IP.
  • Target

    • Function
      Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
    • Pathway
      Protein modification; protein ubiquitination.
    • Sequence similarities
      Contains 1 F-box domain.
      Contains 1 FBA (F-box associated) domain.
    • Cellular localization
      Cytoplasm. Microsome membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • F box gene 1 antibody
      • F box only protein 2 antibody
      • F box protein 2 antibody
      • F box protein only 2 antibody
      • F-box only protein 2 antibody
      • FBG 1 antibody
      • FBG1 antibody
      • Fbs 1 antibody
      • Fbs1 antibody
      • Fbs2 antibody
      • FBX 2 antibody
      • FBX2 antibody
      • FBX2_HUMAN antibody
      • FBXO 2 antibody
      • FBXO2 antibody
      • Neural F box protein NFB42 antibody
      • Neural F-box protein, 42-KD, rat, homolog of antibody
      • NFB 42 antibody
      • NFB42 antibody
      • OCP1 antibody
      • organ of Corti protein 1 antibody
      • Prpl4 antibody
      see all


    • All lanes : Anti-FBXO2 antibody [EPR7328(2)] (ab133717) at 1/10000 dilution

      Lane 1 : Human fetal brain lysate
      Lane 2 : NIH 3T3 cell lysate
      Lane 3 : Neuro 2a cell lysate
      Lane 4 : Human fetal lung lysate
      Lane 5 : HT29 cell lysate
      Lane 6 : U87 MG cell lysate

      Lysates/proteins at 10 µg per lane.

      All lanes : Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution

      Predicted band size: 33 kDa

    • Flow cytometric analysis of permeabilized NIH 3T3 cells labelling FBXO2 with ab133717 at 1/10 (red) or a rabbit IgG negative control antibody (green).
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD


    This product has been referenced in:
    • Schafer ST  et al. Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. Nat Neurosci N/A:N/A (2019). Flow Cyt . Read more (PubMed: 30617258) »
    • Liu B  et al. Aberrant Expression of Fbxo2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice. Diabetes : (2016). Read more (PubMed: 27932386) »
    See all 2 Publications for this product

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