Key features and details
- Rabbit polyclonal to FBXO31 - C-terminal
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-FBXO31 antibody - C-terminal
See all FBXO31 primary antibodies
DescriptionRabbit polyclonal to FBXO31 - C-terminal
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide corresponding to Human FBXO31 (C terminal). NP_079011.
Database link: Q5XUX0
- Human gastric cancer and colon cancer tissues.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab198865 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionComponent of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
Tissue specificityHighly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesBelongs to the FBXO31 family.
Contains 1 F-box domain.
Developmental stageExpression is cell-cycle regulated, and peaks at late G2 to early G1 phase (at protein level).
modificationsPhosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.
- Information by UniProt
- DKFZp434B027 antibody
- DKFZp434J1815 antibody
- F box only protein 31 antibody
ab198865 has not yet been referenced specifically in any publications.