Overview

  • Product name

    Anti-FBXO31 antibody - C-terminal
    See all FBXO31 primary antibodies
  • Description

    Rabbit polyclonal to FBXO31 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human FBXO31 (C terminal). NP_079011.
    Database link: Q5XUX0

  • Positive control

    • Human gastric cancer and colon cancer tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab198865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
  • Tissue specificity

    Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Belongs to the FBXO31 family.
    Contains 1 F-box domain.
  • Developmental stage

    Expression is cell-cycle regulated, and peaks at late G2 to early G1 phase (at protein level).
  • Post-translational
    modifications

    Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp434B027 antibody
    • DKFZp434J1815 antibody
    • F box only protein 31 antibody
    • F box protein 31 antibody
    • F-box only protein 31 antibody
    • FBX14 antibody
    • FBX31 antibody
    • FBX31_HUMAN antibody
    • FBXO14 antibody
    • Fbxo31 antibody
    • FLJ22477 antibody
    • MGC15419 antibody
    • MGC9527 antibody
    • pp2386 antibody
    • Putative breast cancer tumor suppressor antibody
    • SCF ubiquitin ligase specificity factor antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling FBXO31 with ab198865 at 1/40 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling FBXO31 with ab198865 at 1/40 dilution.

References

ab198865 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab198865.
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