Overview

  • Product name

    Anti-FBXO45 antibody
  • Description

    Rabbit polyclonal to FBXO45
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Drosophila melanogaster, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids 107-156 of Human FBXO45 (NM_001105573).

  • Positive control

    • MCF7 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab136614 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 31 kDa.

Target

  • Function

    Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Belongs to the FBXO45/Fsn family.
    Contains 1 B30.2/SPRY domain.
    Contains 1 F-box domain.
  • Cellular localization

    Cell junction > synapse > postsynaptic cell membrane. Cell junction > synapse > presynaptic cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • F box protein 45 antibody
    • F-box only protein 45 antibody
    • F-box/SPRY domain-containing protein 1 antibody
    • FBSP1_HUMAN antibody
    • FBX45 antibody
    • fbxo45 antibody
    • hFbxo45 antibody
    see all

Images

  • Anti-FBXO45 antibody (ab136614) at 1 µg/ml + MCF7 cell lysate at 10 µg

    Predicted band size: 31 kDa

References

This product has been referenced in:

  • Hebbar N  et al. A Naturally Generated Decoy of the Prostate Apoptosis Response-4 Protein Overcomes Therapy Resistance in Tumors. Cancer Res 77:4039-4050 (2017). Read more (PubMed: 28625975) »
See 1 Publication for this product

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