Key features and details
- Rabbit polyclonal to FBXO7
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-FBXO7 antibody
See all FBXO7 primary antibodies
DescriptionRabbit polyclonal to FBXO7
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Zebrafish
- WB: MCF7 cell lysate.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 2% Sucrose, PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab84129 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 59 kDa.|
FunctionSubstrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.
PathwayProtein modification; protein ubiquitination.
Involvement in diseaseDefects in FBXO7 are the cause of Parkinson disease type 15 (PARK15) [MIM:260300]; also known as parkinsonian-pyramidal syndrome. A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia.
Sequence similaritiesContains 1 F-box domain.
Cellular localizationCytoplasm. Nucleus.
- Information by UniProt
- F box only protein 7 antibody
- F box protein 7 antibody
- F-box only protein 7 antibody
Anti-FBXO7 antibody (ab84129) at 1 µg/ml + MCF7 cell lysate at 10 µg
HRP conjugated anti-Rabbit IgG at 1/50000 dilution
Predicted band size: 59 kDa
Observed band size: 59,70 kDa why is the actual band size different from the predicted?
Western blot analysis of MCF7 cell lysate labeling FBXO7 with ab84129.
ab84129 has been referenced in 1 publication.
- Song T et al. CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory. PLoS Genet 14:e1007165 (2018). PubMed: 29370161