Key features and details
- Rabbit polyclonal to Fbxw7
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Fbxw7 antibody
See all Fbxw7 primary antibodies
DescriptionRabbit polyclonal to Fbxw7
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla
Synthetic peptide corresponding to a region aithin amino acids 50 - 100 of Human Fbxw7 (NP_361014.1)
- Breast carcinoma, O=ovarian carcinoma, pancreatic islet cell tumor, skin melanoma, small cell lung cancer.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: Tris buffered saline, 0.1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab84783 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Note: expected to work on frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionSubstrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Tissue specificityIsoform 1 is widely expressed. Isoform 4 is expressed in brain.
Sequence similaritiesContains 1 F-box domain.
Contains 7 WD repeats.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationCytoplasm; Nucleus; Nucleus > nucleolus and Nucleus > nucleoplasm.
- Information by UniProt
- AGO antibody
- Archipelago antibody
- Archipelago homolog antibody
ab84783 has been referenced in 1 publication.
- Liu H et al. Low expression of the ubiquitin ligase FBXW7 correlates with poor prognosis of patients with colorectal cancer. Int J Clin Exp Pathol 11:413-419 (2018). PubMed: 31938126