• Product name

  • Description

    Rabbit polyclonal to Fbxw7
  • Host species

  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to a region aithin amino acids 50 - 100 of Human Fbxw7 (NP_361014.1)

  • Positive control

    • Breast carcinoma, O=ovarian carcinoma, pancreatic islet cell tumor, skin melanoma, small cell lung cancer.



Our Abpromise guarantee covers the use of ab84783 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer may enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
    • Tissue specificity

      Isoform 1 is widely expressed. Isoform 4 is expressed in brain.
    • Sequence similarities

      Contains 1 F-box domain.
      Contains 7 WD repeats.
    • Post-translational

      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization

      Cytoplasm; Nucleus; Nucleus > nucleolus and Nucleus > nucleoplasm.
    • Information by UniProt
    • Database links

    • Alternative names

      • AGO antibody
      • Archipelago antibody
      • Archipelago homolog antibody
      • Archipelago, Drosophila, homolog of antibody
      • CDC4 antibody
      • CDC4, S.cerevisiae, homolog of antibody
      • DKFZp686F23254 antibody
      • F box and WD 40 domain protein 7 (archipelago homolog, Drosophila) antibody
      • F box and WD 40 domain protein 7 antibody
      • F box and WD repeat domain containing 7 antibody
      • F box protein FBW7 antibody
      • F box protein FBX30 antibody
      • F box protein SEL 10 antibody
      • F box protein SEL10 antibody
      • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase antibody
      • F-box and WD-40 domain-containing protein 7 antibody
      • F-box protein FBX30 antibody
      • F-box/WD repeat-containing protein 7 antibody
      • FBW6 antibody
      • FBW7 antibody
      • FBX30 antibody
      • FBXO30 antibody
      • FBXW6 antibody
      • FBXW7 antibody
      • FBXW7_HUMAN antibody
      • FLJ16457 antibody
      • hAgo antibody
      • hCdc4 antibody
      • Homolog of C elegans sel 10 antibody
      • Homolog of C.elegans sel10 antibody
      • SEL 10 antibody
      • SEL-10 antibody
      • SEL10 antibody
      see all


    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human breast carcinoma, using 1/500 ab84783 followed by DAB staining.


    ab84783 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As


    Thank you for your phone call yesterday. I have heard back from the production lab, and I was told the following regarding the concentration of ab84783: "We do not have the precise concentration of IgG in this antibody, as the antibody is prepared to provide specific IHC staining within the recommended range of dilutions.  The concentration of IgG is less than or equal to 1 mg/ml.  To run a normal rabbit IgG as a control, assuming 1 mg/ml for the concentration of IgG in the IHC antibody is reasonable." I hope this information is helpful, but please let me know if you have any further questions.

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