Overview

  • Product name

  • Description

    Rabbit polyclonal to FCRL2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human FCRL2 aa 20-100.
    Database link: Q96LA5

  • Positive control

    • WB: HEK-293T whole cell lysate. IHC-P: Human lung cancer and gastric cancer tissues.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab230318 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
IHC-P 1/20 - 1/200.

Target

  • Function

    May have an regulatory role in normal and neoplastic B cell development.
  • Tissue specificity

    Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B-cells (at protein level).
  • Sequence similarities

    Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Domain

    Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6.
  • Post-translational
    modifications

    Isoform 2 is N- and O-glycosylated, and phosphorylated.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD307b antibody
    • Fc receptor homolog 2 antibody
    • Fc receptor like protein 2 antibody
    • Fc receptor-like protein 2 antibody
    • FcR-like protein 2 antibody
    • FcRH2 antibody
    • FCRL 2 antibody
    • FcRL2 antibody
    • FCRL2_HUMAN antibody
    • IFGP family protein 4 antibody
    • IFGP4 antibody
    • Immunoglobulin receptor translocation associated 4 protein antibody
    • Immunoglobulin receptor translocation-associated protein 4 antibody
    • IRTA4 antibody
    • SH2 domain containing phosphatase anchor protein 1 antibody
    • SH2 domain-containing phosphatase anchor protein 1 antibody
    • SPAP1 antibody
    see all

Images

  • Anti-FCRL2 antibody (ab230318) at 1/1000 dilution + HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution

    Predicted band size: 56 kDa
    Observed band size: 56 kDa

  • Paraffin-embedded human lung cancer tissue stained for FCRL2 using ab230318 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human gastric cancer tissue stained for FCRL2 using ab230318 at 1/100 dilution in immunohistochemical analysis.

References

ab230318 has not yet been referenced specifically in any publications.

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