Overview

  • Product name
    Anti-FCRL3 antibody - C-terminal
    See all FCRL3 primary antibodies
  • Description
    Rabbit polyclonal to FCRL3 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 694-720 of Human FCRL3 (NP_443171.2).

  • Positive control
    • NCI-H460 cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab156137 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab156137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 81 kDa.

Target

  • Tissue specificity
    Primarily expressed in secondary lymphoid tissues by mature subsets of B cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B cells but also expressed in NK cells (at protein level).
  • Involvement in disease
    Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
    Genetic variation in FCRL3 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.
  • Sequence similarities
    Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • Post-translational
    modifications
    Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD307c antibody
    • Fc receptor homolog 3 antibody
    • Fc receptor-like protein 3 antibody
    • FcR-like protein 3 antibody
    • FcRH3 antibody
    • FcRL3 antibody
    • FCRL3_HUMAN antibody
    • hIFGP3 antibody
    • IFGP family protein 3 antibody
    • IFGP3 antibody
    • Immune receptor translocation-associated protein 3 antibody
    • Immunoglobulin superfamily receptor translocation associated protein 3 antibody
    • IRTA3 antibody
    • SH2 domain-containing phosphatase anchor protein 2 antibody
    • SPAP2 antibody
    see all

Images

  • Anti-FCRL3 antibody - C-terminal (ab156137) at 1/100 dilution + NCI-H460 cell lysate at 35 µg

    Predicted band size: 81 kDa

References

ab156137 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab156137.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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