Recombinant
RabMAb

Recombinant Anti-FCRL4 antibody [EPR21961] (ab239076)

Overview

  • Product name

    Anti-FCRL4 antibody [EPR21961]
    See all FCRL4 primary antibodies
  • Description

    Rabbit monoclonal [EPR21961] to FCRL4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human FCRL4 aa 1-400. The exact sequence is proprietary.
    Database link: Q96PJ5

  • Positive control

    • IHC-P: Human tonsil and mrginal zone lymphoma tissue.
  • General notes

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.01% Sodium azide
    Constituents: PBS, 40% Glycerol, 0.05% BSA
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    EPR21961
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab239076 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/500. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Heat mediated antigen retrieval using ab93684 (Tris/EDTA buffer, pH 9.0).

Target

  • Function

    May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
  • Tissue specificity

    Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).
  • Involvement in disease

    Note=A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).
    Note=A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
  • Sequence similarities

    Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Post-translational
    modifications

    Phosphorylated on cytoplasmic tyrosines upon activation.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD307d antibody
    • Fc receptor homolog 4 antibody
    • Fc receptor like 4 antibody
    • Fc receptor like protein 4 antibody
    • Fc receptor-like protein 4 antibody
    • FcR like protein 4 antibody
    • FcR-like protein 4 antibody
    • FcRH4 antibody
    • FcRL4 antibody
    • FCRL4_HUMAN antibody
    • hIFGP2 antibody
    • IFGP family protein 2 antibody
    • IGFP2 antibody
    • Immune receptor translocation associated protein 1 antibody
    • Immune receptor translocation-associated protein 1 antibody
    • Immunoglobulin superfamily receptor translocation associated 1 antibody
    • Immunoglobulin superfamily receptor translocation associated gene 1 antibody
    • IRTA1 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded marginal zone lymphoma tissue labeling FCRL4 with ab239076 at 1/500 dilution, followed by a ready to use Goat Anti-Rabbit IgG H&L (HRP) antibody. Cytoplasmic and membranous staining on the marginal zone lymphoma cells (PMID:12881317) is observed. Counterstained with hematoxylin.

    Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) ready to use.

    Heat mediated antigen retrieval using ab93684 (Tris/EDTA buffer, pH 9.0).

  • Immunohistochemical analysis of paraffin-embedded human tonsil tissue labeling FCRL4 with ab239076 at 1/500 dilution, followed by a ready to use Goat Anti-Rabbit IgG H&L (HRP) antibody. Cytoplasmic and membranous staining on a subset of lymphocytes in human tonsil (PMID:12881317) is observed. Counterstained with hematoxylin.

    Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) ready to use.

    Heat mediated antigen retrieval using ab93684 (Tris/EDTA buffer, pH 9.0).

References

ab239076 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab239076.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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