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    fdpsfps-antibody-ab153805.pdf

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Cardiovascular Lipids / Lipoproteins Lipid Metabolism Cholesterol Metabolism
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Anti-FDPS/FPS antibody (ab153805)

  • Datasheet
  • SDS
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Western blot - Anti-FDPS/FPS antibody (ab153805)
  • Western blot - Anti-FDPS/FPS antibody (ab153805)
  • Immunocytochemistry/ Immunofluorescence - Anti-FDPS/FPS antibody (ab153805)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FDPS/FPS antibody (ab153805)

Key features and details

  • Rabbit polyclonal to FDPS/FPS
  • Suitable for: WB, IHC-P, ICC/IF
  • Reacts with: Mouse, Human
  • Isotype: IgG

You may also be interested in

Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-FDPS/FPS antibody
    See all FDPS/FPS primary antibodies
  • Description

    Rabbit polyclonal to FDPS/FPS
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow, Pig
  • Immunogen

    Recombinant fragment corresponding to Human FDPS/FPS aa 43-381.

  • Positive control

    • A549, HeLa, HepG2, HCT116 and mouse brain lysates; HeLa cells; Ca922 xenograft.
  • General notes

    Previously labelled as FDPS. 

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.025% Proclin 300
    Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cardiovascular
    • Lipids / Lipoproteins
    • Lipid Metabolism
    • Cholesterol Metabolism
    • Signal Transduction
    • Metabolism
    • Lipid metabolism
    • Cancer
    • Tumor biomarkers
    • Other
    • Cancer
    • Tumor biomarkers
    • Enzymes
    • Other
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Cholesterol Metabolism

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HeLa whole cell lysate (ab150035)
    • HeLa whole cell lysate (ab29545)
    • Mouse brain tissue lysate - total protein (ab30151)
    • A549 whole cell lysate (ab7910)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab153805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/1000 - 1/10000. Predicted molecular weight: 48 kDa.
IHC-P
1/100 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).
ICC/IF
1/100 - 1/1000.
Notes
WB
1/1000 - 1/10000. Predicted molecular weight: 48 kDa.
IHC-P
1/100 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).
ICC/IF
1/100 - 1/1000.

Target

  • Function

    Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
  • Pathway

    Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
    Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
  • Sequence similarities

    Belongs to the FPP/GGPP synthase family.
  • Cellular localization

    Cytoplasm.
  • Target information above from: UniProt accession P14324 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 281156 Cow
    • Entrez Gene: 2224 Human
    • Entrez Gene: 110196 Mouse
    • Entrez Gene: 100153932 Pig
    • Entrez Gene: 83791 Rat
    • Omim: 134629 Human
    • SwissProt: Q8WMY2 Cow
    • SwissProt: P14324 Human
    • SwissProt: Q920E5 Mouse
    • SwissProt: P05369 Rat
    • Unigene: 335918 Human
    • Unigene: 39472 Mouse
    • Unigene: 2848 Rat
    see all
  • Alternative names

    • (2E antibody
    • (2E,6E) farnesyl diphosphate synthase antibody
    • 6E)-farnesyl diphosphate synthase antibody
    • Dimethylallyltranstransferase antibody
    • Farnesyl diphosphate synthase antibody
    • Farnesyl diphosphate synthetase antibody
    • Farnesyl pyrophosphate synthase antibody
    • Farnesyl pyrophosphate synthetase antibody
    • Fdps antibody
    • FPP synthase antibody
    • FPP synthetase antibody
    • FPPS antibody
    • FPPS_HUMAN antibody
    • FPS antibody
    • Geranyltranstransferase antibody
    see all

Images

  • Western blot - Anti-FDPS/FPS antibody (ab153805)
    Western blot - Anti-FDPS/FPS antibody (ab153805)
    Anti-FDPS/FPS antibody (ab153805) at 1/10000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size: 48 kDa



    10% SDS PAGE
  • Western blot - Anti-FDPS/FPS antibody (ab153805)
    Western blot - Anti-FDPS/FPS antibody (ab153805)
    Anti-FDPS/FPS antibody (ab153805) at 1/3000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size: 48 kDa



    10% SDS PAGE
  • Immunocytochemistry/ Immunofluorescence - Anti-FDPS/FPS antibody (ab153805)
    Immunocytochemistry/ Immunofluorescence - Anti-FDPS/FPS antibody (ab153805)

    Immunofluorescent analysis of methanol-fixed HeLa cells labeling FDPS/FPS with ab153805 at 1/200 dilution. Lower panel co-stained with Hoechst 33342.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FDPS/FPS antibody (ab153805)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FDPS/FPS antibody (ab153805)

    Immunohistochemical analysis of paraffin-embedded Ca922 xenograft labeling FDPS/FPS with ab153805 at 1/500 dilution.

Protocols

  • Immunohistochemistry protocols
  • Immunocytochemistry & immunofluorescence protocols
  • Western blot protocols

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (4)

Publishing research using ab153805? Please let us know so that we can cite the reference in this datasheet.

ab153805 has been referenced in 4 publications.

  • Pinner AL  et al. Protein expression of prenyltransferase subunits in postmortem schizophrenia dorsolateral prefrontal cortex. Transl Psychiatry 10:3 (2020). PubMed: 32066669
  • Fiore D  et al. N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor. Cancers (Basel) 11:N/A (2019). PubMed: 31569395
  • Kim HY  et al. Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness. Exp Mol Med 50:137 (2018). PubMed: 30333528
  • Du CQ  et al. Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells. Int J Mol Med 35:1767-72 (2015). PubMed: 25847782

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