Overview

  • Product name

  • Description

    Rabbit polyclonal to FDPS/FPS
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow, Pig
  • Immunogen

    Recombinant fragment corresponding to Human FDPS/FPS aa 43-381.

  • Positive control

    • A549, HeLa, HepG2, HCT116 and mouse brain lysates; HeLa cells; Ca922 xenograft.
  • General notes

    Previously labelled as FDPS. 

Properties

Applications

Our Abpromise guarantee covers the use of ab153805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 48 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).
ICC/IF 1/100 - 1/1000.

Target

  • Function

    Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
  • Pathway

    Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
    Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
  • Sequence similarities

    Belongs to the FPP/GGPP synthase family.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • (2E antibody
    • (2E,6E) farnesyl diphosphate synthase antibody
    • 6E)-farnesyl diphosphate synthase antibody
    • Dimethylallyltranstransferase antibody
    • Farnesyl diphosphate synthase antibody
    • Farnesyl diphosphate synthetase antibody
    • Farnesyl pyrophosphate synthase antibody
    • Farnesyl pyrophosphate synthetase antibody
    • Fdps antibody
    • FPP synthase antibody
    • FPP synthetase antibody
    • FPPS antibody
    • FPPS_HUMAN antibody
    • FPS antibody
    • Geranyltranstransferase antibody
    see all

Images

  • Anti-FDPS/FPS antibody (ab153805) at 1/10000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size: 48 kDa



    10% SDS PAGE
  • Anti-FDPS/FPS antibody (ab153805) at 1/3000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size: 48 kDa



    10% SDS PAGE
  • Immunofluorescent analysis of methanol-fixed HeLa cells labeling FDPS/FPS with ab153805 at 1/200 dilution. Lower panel co-stained with Hoechst 33342.

  • Immunohistochemical analysis of paraffin-embedded Ca922 xenograft labeling FDPS/FPS with ab153805 at 1/500 dilution.

References

This product has been referenced in:

  • Kim HY  et al. Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness. Exp Mol Med 50:137 (2018). Read more (PubMed: 30333528) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab153805.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up