Overview

  • Product name

  • Description

    Rabbit polyclonal to FDPS/FPS
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human FDPS/FPS aa 389-419 (internal sequence) conjugated to keyhole limpet haemocyanin.
    Database link: P14324

  • Positive control

    • WB: Human cytokeratin liver cell lysate, IHC-P: Human hepatocarcinoma tissue.
  • General notes

    Previously labelled as FDPS. 

Properties

Applications

Our Abpromise guarantee covers the use of ab38854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 44 kDa (predicted molecular weight: 41 kDa).
IHC-P 1/10 - 1/50.

Target

  • Function

    Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
  • Pathway

    Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
    Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
  • Sequence similarities

    Belongs to the FPP/GGPP synthase family.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • (2E antibody
    • (2E,6E) farnesyl diphosphate synthase antibody
    • 6E)-farnesyl diphosphate synthase antibody
    • Dimethylallyltranstransferase antibody
    • Farnesyl diphosphate synthase antibody
    • Farnesyl diphosphate synthetase antibody
    • Farnesyl pyrophosphate synthase antibody
    • Farnesyl pyrophosphate synthetase antibody
    • Fdps antibody
    • FPP synthase antibody
    • FPP synthetase antibody
    • FPPS antibody
    • FPPS_HUMAN antibody
    • FPS antibody
    • Geranyltranstransferase antibody
    see all

Images

  • Anti-FDPS/FPS antibody (ab38854) + Human cytokeratin liver cell lysate

    Predicted band size: 41 kDa
    Observed band size: 44 kDa
    why is the actual band size different from the predicted?

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human hepatocarcinoma tissue labelling FDPS/FPS with ab38854. A peroxidase-conjugated anti-rabbit IgG was used as the secondary antibody, followed by DAB staining.

References

This product has been referenced in:

See all 8 Publications for this product

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