Key features and details
- Rabbit polyclonal to FDPS/FPS - C-terminal
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-FDPS/FPS antibody - C-terminal
See all FDPS/FPS primary antibodies
DescriptionRabbit polyclonal to FDPS/FPS - C-terminal
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Predicted to work with: Cow
Recombinant fragment corresponding to Human FDPS/FPS aa 120-419 (C terminal).
IGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVAD DIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYY LNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAF YSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPS VTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKA LYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Database link: P14324
Previously labelled as FDPS.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab189874 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 48 kDa.|
FunctionKey enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
PathwayIsoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Sequence similaritiesBelongs to the FPP/GGPP synthase family.
- Information by UniProt
- (2E antibody
- (2E,6E) farnesyl diphosphate synthase antibody
- 6E)-farnesyl diphosphate synthase antibody
All lanes : Anti-FDPS/FPS antibody - C-terminal (ab189874) at 1/500 dilution
Lane 1 : 293T cell line extract
Lane 2 : HepG2 cell line extract
Lane 3 : HeLa cell line extract
Lane 4 : MCF7 cell line extract
Lane 5 : U-251MG cell line extract
Lane 6 : BxPC3 cell line extract
Lane 7 : Mouse liver extract
Lane 8 : Mouse ovary extract
Predicted band size: 48 kDa
ab189874 has been referenced in 4 publications.
- Kang H et al. HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways. Cancers (Basel) 11:N/A (2019). PubMed: 31540279
- Kim YS et al. Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism. Int J Mol Sci 19:N/A (2018). PubMed: 30321984
- Jiang D et al. Expression of key enzymes in the mevalonate pathway are altered in monocrotaline-induced pulmonary arterial hypertension in rats. Mol Med Rep 16:9593-9600 (2017). PubMed: 29039598
- Kühl I et al. Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals. Elife 6:N/A (2017). PubMed: 29132502