Product nameAnti-FDPS/FPS antibody - C-terminal
See all FDPS/FPS primary antibodies
DescriptionRabbit polyclonal to FDPS/FPS - C-terminal
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Mouse, Rat, Human
Predicted to work with: Cow
Recombinant fragment corresponding to Human FDPS/FPS aa 120-419 (C terminal).
IGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVAD DIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYY LNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAF YSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPS VTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKA LYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Database link: P14324
- 293T, HepG2, MCF7, U-251MG, BxPC3, Mouse liver and Mouse ovary extracts.
Previously labelled as FDPS.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab189874 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 48 kDa.|
|IHC-P||1/50 - 1/200.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
FunctionKey enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
PathwayIsoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Sequence similaritiesBelongs to the FPP/GGPP synthase family.
- Information by UniProt
- (2E antibody
- (2E,6E) farnesyl diphosphate synthase antibody
- 6E)-farnesyl diphosphate synthase antibody
All lanes : Anti-FDPS/FPS antibody - C-terminal (ab189874) at 1/500 dilution
Lane 1 : 293T cell line extract
Lane 2 : HepG2 cell line extract
Lane 3 : HeLa cell line extract
Lane 4 : MCF7 cell line extract
Lane 5 : U-251MG cell line extract
Lane 6 : BxPC3 cell line extract
Lane 7 : Mouse liver extract
Lane 8 : Mouse ovary extract
Predicted band size: 48 kDa
This product has been referenced in:
- Kim YS et al. Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism. Int J Mol Sci 19:N/A (2018). Read more (PubMed: 30321984) »
- Kühl I et al. Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals. Elife 6:N/A (2017). Read more (PubMed: 29132502) »