Overview

  • Product name

    Anti-FDPS/FPS antibody [EPR4628]
    See all FDPS/FPS primary antibodies
  • Description

    Rabbit monoclonal [EPR4628] to FDPS/FPS
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, Flow Cytmore details
    Unsuitable for: ICC or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human FDPS/FPS aa 350-450 (C terminal). The exact sequence is proprietary.

  • Positive control

    • THP1, HepG2, and Human fetal liver lysates; Human kidney tissue.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Previously labelled as FDPS. 

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab109007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 48 kDa.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Heat up to 98 degrees C, below boiling, and then let cool for 10-20 min.
Flow Cyt 1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

 

  • Application notes
    Is unsuitable for ICC or IP.
  • Target

    • Function

      Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
    • Pathway

      Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
      Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
    • Sequence similarities

      Belongs to the FPP/GGPP synthase family.
    • Cellular localization

      Cytoplasm.
    • Information by UniProt
    • Database links

    • Alternative names

      • (2E antibody
      • (2E,6E) farnesyl diphosphate synthase antibody
      • 6E)-farnesyl diphosphate synthase antibody
      • Dimethylallyltranstransferase antibody
      • Farnesyl diphosphate synthase antibody
      • Farnesyl diphosphate synthetase antibody
      • Farnesyl pyrophosphate synthase antibody
      • Farnesyl pyrophosphate synthetase antibody
      • Fdps antibody
      • FPP synthase antibody
      • FPP synthetase antibody
      • FPPS antibody
      • FPPS_HUMAN antibody
      • FPS antibody
      • Geranyltranstransferase antibody
      see all

    Images

    • All lanes : Anti-FDPS/FPS antibody [EPR4628] (ab109007) at 1/1000 dilution

      Lane 1 : THP1 cell lysates
      Lane 2 : HepG2 cell lysates
      Lane 3 : Human fetal liver lysates

      Predicted band size: 48 kDa

    • ab109007 at 1/100 dilution staining FDPS/FPS in Human kidney by Immunohistochemistry, Paraffin-embedded tissue.

      Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    References

    ab109007 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab109007.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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