Febuxostat, non-purine xanthine oxidase inhibitor (ab143619)

Overview

  • Product name

    Febuxostat, non-purine xanthine oxidase inhibitor
  • Description

    Highly potent, selective, non-competitive, non-purine xanthine oxidase inhibitor
  • Biological description

    Highly potent, selective, non-competitive, non-purine xanthine oxidase inhibitor (Ki = 0.6 nM). Inhibits xanthine dehydrogenase. Reduces uric acid and ROS levels. Shows antihyperuricemic, anti-ischemic, cardioprotective and renoprotective effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    144060-53-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Nomura J  et al. Xanthine oxidase inhibition by febuxostat attenuates experimental atherosclerosis in mice. Sci Rep 4:4554 (2014). Read more (PubMed: 24686534) »
  • Krishna Reddy RC  et al. New urea and thiourea derivatives of piperazine doped with febuxostat: synthesis and evaluation of anti-TMV and antimicrobial activities. ScientificWorldJournal 2013:682603 (2013). Read more (PubMed: 24453889) »
  • Tsuda H  et al. Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress. Biochem Biophys Res Commun 427:266-72 (2012). Read more (PubMed: 22995295) »

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