Overview

  • Product name

    Felodipine, L-type Ca2+ channel blocker
  • Description

    Selective L-type Ca2+ channel blocker
  • Biological description

    Selective L-type Ca2+ channel blocker. Selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity and shows antihypertensive effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    72509-76-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-O-Ethyl 3-O-methyl-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Molecular weight

    384.25
  • Molecular formula

    C18H19Cl2NO4
  • PubChem identifier

    3333
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
  • Source

    Synthetic

  • Research areas

Images

  • Felodipine blocks L-type Ca2+ currents in Xenopus oocytes.

    Superimposed current traces of L-type channels (CaV1.2+a2d1+ß1a), before and during applications of 1 and 10 µM Felodipine (ab141797) as indicated on the left. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to +10 mV.

References

This product has been referenced in:

  • Surya Sandeep M  et al. Enhanced oral bioavailability of felodipine by naringenin in Wistar rats and inhibition of P-glycoprotein in everted rat gut sacs in vitro. Drug Dev Ind Pharm : (2013). Read more (PubMed: 23883365) »
  • Furukawa T  et al. Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther 291:464-73 (1999). Read more (PubMed: 10525060) »
  • Ljung B Vascular selectivity of felodipine: experimental pharmacology. J Cardiovasc Pharmacol 15 Suppl 4:S11-6 (1990). Read more (PubMed: 1693715) »

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