Product nameFEM 1B peptide
See all FEM 1B proteins and peptides
Our Abpromise guarantee covers the use of ab6098 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Stable for one year.
F1A alpha, also termed FEM1 beta, is a novel protein that associates with the intracellular domains of Fas and TNFR1. Over expression of F1A alpha induces apoptosis. F1A alpha also associates with CED-4 and its mammalian homologue Apaf-1, and can be cleaved by CED-3 and caspases.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2
- F1A alpha
FunctionComponent of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Tissue specificityWidely expressed. Highly expressed in testis. Weakly expressed in other tissues.
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesBelongs to the fem-1 family.
Contains 8 ANK repeats.
Contains 1 TPR repeat.
Cellular localizationCytoplasm. Nucleus. In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.
- Information by UniProt
ab6098 has not yet been referenced specifically in any publications.