Overview

  • Product name

    Fenbufen, COX inhibitor
  • Description

    COX inhibitor. NSAID.
  • Biological description

    COX inhibitor (IC50 values are 4 and 8 μM for COX-1 and COX-2 respectively). NSAID. Potently inhibits prostaglandin synthesis. Shows anti-inflammatory and analgesic effects in vivo. Shows a similar spectrum and potency of activity as Phenylbutazone (Asc 2930). Orally active.
  • Purity

    > 98%
  • CAS Number

    36330-85-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Oxo-4-(4-phenylphenyl)butanoic acid
  • Molecular weight

    254.28
  • Molecular formula

    C16H14O3
  • PubChem identifier

    3335
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)CCC(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Huang HL  et al. [123I]Iodooctyl fenbufen amide as a SPECT tracer for imaging tumors that over-express COX enzymes. Biomaterials 34:3355-65 (2013). Read more (PubMed: 23384791) »
  • Sloboda AE  et al. The pharmacological properties of fenbufen. A review. Arzneimittelforschung 30:716-21 (1980). Read more (PubMed: 7002162) »
  • Child RG  et al. Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs. J Pharm Sci 66:466-76 (1977). Read more (PubMed: 300797) »

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