Overview

  • Product name
    Fenobam, mGlu5 antagonist
  • Description
    Selective, potent, orally active mGlu5 antagonist
  • Biological description
    Selective, potent mGlu5 receptor antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM at rat and human recombinant mGlu5 receptors, respectively). Displays inverse agonist properties and blocks mGlu5 receptor basal activity (IC50 = 84 nM). Orally active, atypical anxiolytic.
  • Purity
    > 99%
  • CAS Number
    57653-26-6
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Lax NC  et al. The mGluR5 antagonist fenobam induces analgesic conditioned place preference in mice with spared nerve injury. PLoS One 9:e103524 (2014). Read more (PubMed: 25061818) »
  • Wållberg A  et al. Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues. Bioorg Med Chem Lett 16:1142-5 (2006). Read more (PubMed: 16380255) »
  • Porter RH  et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther 315:711-21 (2005). Read more (PubMed: 16040814) »
  • Goldberg ME  et al. Novel non-benzodiazepine anxiolytics. Neuropharmacology 22:1499-504 (1983). Read more (PubMed: 6142427) »

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